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    FGF22 fibroblast growth factor 22 [ Homo sapiens (human) ]

    Gene ID: 27006, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FGF22provided by HGNC
    Official Full Name
    fibroblast growth factor 22provided by HGNC
    Primary source
    HGNC:HGNC:3679
    See related
    Ensembl:ENSG00000070388 MIM:605831; AllianceGenome:HGNC:3679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in skin (RPKM 1.5), brain (RPKM 0.4) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FGF22 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (639879..644373)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (594185..598645)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (639879..644373)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC107987266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13566 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:613339-613520 Neighboring gene RNA polymerase mitochondrial Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:629803-630486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9611 Neighboring gene uncharacterized LOC105372234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:638495-639220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:644145-645085 Neighboring gene ring finger protein 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:657815-658727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:658728-659641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:678746-679248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:680933-681482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:681483-682031 Neighboring gene follistatin like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrated Analysis of Transcriptome and Prognosis Data Identifies FGF22 as a Prognostic Marker of Lung Adenocarcinoma. Liu HY, et al. Technol Cancer Res Treat, 2019 Jan 1. PMID 30803369, Free PMC Article
    2. Highly efficient production of functional recombinant human fibroblast growth factor 22 in E. coli and its protective effects on H(2)O(2)-lesioned L02 cells. Yang H, et al. Protein Expr Purif, 2018 Dec. PMID 29627393
    3. Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β. Xu YH, et al. CNS Neurosci Ther, 2017 Nov. PMID 28948716, Free PMC Article
    4. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. Nakatake Y, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342227
    5. FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer. Zhang Z, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Jul 28. PMID 34117747

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.
      Title: FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.
    2. FGF22 displays protective, antioxidant, and mitogenic effect on mammalian cells.
      Title: Highly efficient production of functional recombinant human fibroblast growth factor 22 in E. coli and its protective effects on H(2)O(2)-lesioned L02 cells.
    3. High FGF22 expression is associated with Lung Adenocarcinoma.
      Title: Integrated Analysis of Transcriptome and Prognosis Data Identifies FGF22 as a Prognostic Marker of Lung Adenocarcinoma.
    4. This study showed that serum FGF22 levels in depressive patients were negatively correlated with serum IL-1beta levels. In animal and cell experiments, enhancing the levels of FGF22 in rat hippocampus was demonstrated to alleviate the chronic unpredictable mild stress-induced depression. The increase in FGF22 was found to be associated with reduced IL-1beta expression and hippocampal apoptosis.
      Title: Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor 22
    Names
    FGF-22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300812.3 → NP_001287741.1  fibroblast growth factor 22 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC004449
      Consensus CDS
      CCDS74241.1
      UniProtKB/TrEMBL
      K7ELB9
      Related
      ENSP00000466004.1, ENST00000586042.6
      Conserved Domains (1) summary
      cl00060
      Location:41 → 106
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    2. NM_020637.2 → NP_065688.1  fibroblast growth factor 22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_065688.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC004449
      Consensus CDS
      CCDS12037.1
      UniProtKB/Swiss-Prot
      B2RPH4, Q9HCT0
      UniProtKB/TrEMBL
      A0A7U3JVZ9
      Related
      ENSP00000215530.4, ENST00000215530.7
      Conserved Domains (1) summary
      smart00442
      Location:39 → 167
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      639879..644373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      594185..598645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCT0.1 GenPept UniProtKB/Swiss-Prot:Q9HCT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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