ING2 inhibitor of growth family member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ING2provided by HGNC
Official Full Name: inhibitor of growth family member 2provided by HGNC
Primary source: HGNC:HGNC:6063
See related: Ensembl:ENSG00000168556 MIM:604215; AllianceGenome:HGNC:6063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ING1L; p33ING2
Summary: This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q35.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (183505058..183512429)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (186847848..186855219)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (184426211..184433582)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis.
Title: ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis.
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Title: Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
Title: Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
Findings provide evidence that ING2 is a direct target of miR92a.
Title: miR‑92a contributes to cell proliferation, apoptosis and doxorubicin chemosensitivity in gastric carcinoma cells.
Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
Title: A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis.
Title: Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.
Results suggest that ING2 acts as a tumor suppressor in osteosarcoma.
Title: Nuclear ING2 expression is reduced in osteosarcoma.
It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.
Title: A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2.
Decreased expression of ING2 gene is associated with non-small cell lung cancer.
Title: Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients.
It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer.
Title: Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131506 (e-PCR)
- UniSTS:214789

ING1L_8420 (e-PCR)
- UniSTS:467727

RH36386 (e-PCR)
- UniSTS:9195

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	TAS Traceable Author Statement more info	PubMed
enables histone deacetylase regulator activity	TAS Traceable Author Statement more info	PubMed
enables histone reader activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	NAS Non-traceable Author Statement more info	PubMed
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in male germ-line stem cell asymmetric division	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in male meiosis I	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression, epigenetic	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular senescence	NAS Non-traceable Author Statement more info	PubMed
involved_in seminiferous tubule development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in spermatid development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of Sin3-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: inhibitor of growth protein 2

Names: ING1Lp; inhibitor of growth 1-like protein; p32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291959.2 → NP_001278888.1 inhibitor of growth protein 2 isoform 2

See identical proteins and their annotated locations for NP_001278888.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in translation initiation from an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC107214, AK294310, BC030128

UniProtKB/Swiss-Prot

Q9H160

Conserved Domains (2) summary

cd15683
Location:173 → 221

PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)

pfam12998
Location:18 → 81

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_001564.4 → NP_001555.1 inhibitor of growth protein 2 isoform 1

See identical proteins and their annotated locations for NP_001555.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB012853, AC107214, AK314000, BC030128

Consensus CDS

CCDS3833.1

UniProtKB/Swiss-Prot

B6ZDS1, O95698, Q9H160

UniProtKB/TrEMBL

B2RA15

Related

ENSP00000307183.3, ENST00000302327.4

Conserved Domains (2) summary

cd15683
Location:213 → 261

PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)

cd16861
Location:32 → 119

ING_ING2; Inhibitor of growth (ING) domain of inhibitor of growth protein 2 (ING2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

183505058..183512429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011531927.3 → XP_011530229.1 inhibitor of growth protein 2 isoform X1

See identical proteins and their annotated locations for XP_011530229.1

Conserved Domains (2) summary

cd15683
Location:158 → 206

PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)

pfam12998
Location:3 → 66

ING; Inhibitor of growth proteins N-terminal histone-binding