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    FRT1 Frt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854503, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRT1
    Official Full Name
    Frt1p
    Primary source
    SGD:S000005851
    Locus tag
    YOR324C
    See related
    AllianceGenome:SGD:S000005851; FungiDB:YOR324C; VEuPathDB:YOR324C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HPH1
    Summary
    Involved in cellular response to alkaline pH and cellular response to salt stress. Acts upstream of or within posttranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FRT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (923232..925040, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ldb19p Neighboring gene glutamate-5-semialdehyde dehydrogenase Neighboring gene myosin 2 Neighboring gene SNAP receptor SNC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequencing of a 35.71 kb DNA segment on the right arm of yeast chromosome XV reveals regions of similarity to chromosomes I and XIII. Pearson BM, et al. Yeast, 1996 Sep. PMID 8896266
    2. A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function. Roy J, et al. Mol Cell, 2007 Mar 23. PMID 17386265, Free PMC Article
    3. Genetic architecture of Hsp90-dependent drug resistance. Cowen LE, et al. Eukaryot Cell, 2006 Dec. PMID 17056742, Free PMC Article
    4. Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Heath VL, et al. Eukaryot Cell, 2004 Jun. PMID 15189990, Free PMC Article
    5. Calcineurin determines toxic versus beneficial responses to α-synuclein. Caraveo G, et al. Proc Natl Acad Sci U S A, 2014 Aug 26. PMID 25122673, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis
      Title: Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.
    2. Calcineurin directly dephosphorylates Hph1p and interacts with it through a sequence motif in Hph1p, PVIAVN
      Title: Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-translational protein targeting to membrane, translocation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Frt1p
    NP_014969.3
    • Tail-anchored ER membrane hypothetical protein; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      923232..925040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183744.3 → NP_014969.3  TPA: Frt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014969.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W322, Q99332
      UniProtKB/TrEMBL
      B3LJY6, B5VSJ8, C7GNT9, C8ZH75, N1P3T7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99332.1

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