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    DLGAP5 DLG associated protein 5 [ Homo sapiens (human) ]

    Gene ID: 9787, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DLGAP5provided by HGNC
    Official Full Name
    DLG associated protein 5provided by HGNC
    Primary source
    HGNC:HGNC:16864
    See related
    Ensembl:ENSG00000126787 MIM:617859; AllianceGenome:HGNC:16864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLG7; HURP
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in cytosol; nucleus; and spindle. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in bone marrow (RPKM 9.4), testis (RPKM 9.1) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DLGAP5 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55148135..55191585, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49353325..49396782, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55614853..55658303, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8427 Neighboring gene Sharpr-MPRA regulatory region 5571 Neighboring gene galectin 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:55657493-55658046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:55658047-55658599 Neighboring gene uncharacterized LOC105370508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:55662229-55662728 Neighboring gene uncharacterized LOC107984708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer. Chang ML, et al. PLoS One, 2011. PMID 22022601, Free PMC Article
    2. Prognostic and predictive value of HURP in non‑small cell lung cancer. Wang Q, et al. Oncol Rep, 2018 Apr. PMID 29484418, Free PMC Article
    3. A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Hewit K, et al. Cell Death Dis, 2018 Oct 19. PMID 30341281, Free PMC Article
    4. Evaluation of urinary HURP mRNA as a marker for detection of bladder cancer: relation to bilharziasis. Eissa S, et al. Med Oncol, 2014 Feb. PMID 24375315
    5. Prognostic value of discs large homolog 7 transcript levels in prostate cancer. Gomez CR, et al. PLoS One, 2013. PMID 24349376, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.
      Title: DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.
    2. DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.
      Title: DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.
    3. circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.
      Title: circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.
    4. DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP.
      Title: DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP.
    5. DLGAP5 knockdown inactivates the Wnt/beta-catenin signal to repress endometrial cancer cell malignant activities.
      Title: DLGAP5 knockdown inactivates the Wnt/β-catenin signal to repress endometrial cancer cell malignant activities.
    6. High Expression of DLGAP5 Indicates Poor Prognosis and Immunotherapy in Lung Adenocarcinoma and Promotes Proliferation through Regulation of the Cell Cycle.
      Title: High Expression of DLGAP5 Indicates Poor Prognosis and Immunotherapy in Lung Adenocarcinoma and Promotes Proliferation through Regulation of the Cell Cycle.
    7. Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome.
      Title: Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome.
    8. Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas.
      Title: Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas.
    9. Pan-cancer analysis and experiments with cell lines reveal that the slightly elevated expression of DLGAP5 is involved in clear cell renal cell carcinoma progression.
      Title: Pan-cancer analysis and experiments with cell lines reveal that the slightly elevated expression of DLGAP5 is involved in clear cell renal cell carcinoma progression.
    10. The expression of hepatoma upregulated protein in human endometrium during the menstrual cycle.
      Title: The expression of hepatoma upregulated protein in human endometrium during the menstrual cycle.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of circulating galectin-3.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0008

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome movement towards spindle pole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disks large-associated protein 5
    Names
    DAP-5
    discs large homolog associated protein 5
    discs, large homolog 7
    disks large-associated protein DLG7
    hepatoma up-regulated protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146015.2 → NP_001139487.1  disks large-associated protein 5 isoform b

      See identical proteins and their annotated locations for NP_001139487.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform b) has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK299338, BM788630, BX248255
      Consensus CDS
      CCDS53897.1
      UniProtKB/TrEMBL
      A8K732
      Related
      ENSP00000378815.2, ENST00000395425.6
      Conserved Domains (1) summary
      pfam03359
      Location:432 → 599
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_014750.5 → NP_055565.3  disks large-associated protein 5 isoform a

      See identical proteins and their annotated locations for NP_055565.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AB076695, BC010658
      Consensus CDS
      CCDS9723.1
      UniProtKB/Swiss-Prot
      A8MTM6, B4DRM8, Q15398, Q86T11, Q8NG58
      UniProtKB/TrEMBL
      A8K732
      Related
      ENSP00000247191.2, ENST00000247191.7
      Conserved Domains (1) summary
      pfam03359
      Location:432 → 599
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      55148135..55191585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021840.3 → XP_016877329.1  disks large-associated protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A8MTM6, B4DRM8, Q15398, Q86T11, Q8NG58
      UniProtKB/TrEMBL
      A8K732
      Conserved Domains (1) summary
      pfam03359
      Location:432 → 599
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. XM_047432016.1 → XP_047287972.1  disks large-associated protein 5 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      49353325..49396782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377137.1 → XP_054233112.1  disks large-associated protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A8MTM6, B4DRM8, Q15398, Q86T11, Q8NG58

    2. XM_054377138.1 → XP_054233113.1  disks large-associated protein 5 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15398.2 GenPept UniProtKB/Swiss-Prot:Q15398

    Gene LinkOut

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