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    ZNF575 zinc finger protein 575 [ Homo sapiens (human) ]

    Gene ID: 284346, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF575provided by HGNC
    Official Full Name
    zinc finger protein 575provided by HGNC
    Primary source
    HGNC:HGNC:27606
    See related
    Ensembl:ENSG00000176472 AllianceGenome:HGNC:27606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in colon (RPKM 2.0), fat (RPKM 1.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF575 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43530835..43536087)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46352369..46357622)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44037340..44040239)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain family B member 3 Neighboring gene Sharpr-MPRA regulatory region 2471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44008034-44008556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44017305-44017805 Neighboring gene ETHE1 persulfide dioxygenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44029999-44030504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44030505-44031009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10721 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44035307-44035478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10722 Neighboring gene X-ray repair cross complementing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44067237-44067737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080053-44080579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44080580-44081105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14727 Neighboring gene phospholipase A2 inhibitor and LY6/PLAUR domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:44098910-44099706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14729 Neighboring gene immunity related GTPase Q

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood. Cardenas A, et al. Clin Epigenetics, 2019 Mar 29. PMID 30925934, Free PMC Article
    2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results found DNA methylation of the ZNF575 gene in infant cord blood to be associated with maternal antidepressant use in pregnancy in two independent cohorts. This association persists into early childhood.
      Title: Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ32567

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 575

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394237.1 → NP_001381166.1  zinc finger protein 575

      Status: VALIDATED

      Source sequence(s)
      AC018758
      Consensus CDS
      CCDS12623.1
      UniProtKB/Swiss-Prot
      B4DX54, Q86XF7
      Related
      ENSP00000472578.1, ENST00000601282.1
      Conserved Domains (2) summary
      PHA03247
      Location:6 → 211
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:93 → 113
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_174945.3 → NP_777605.1  zinc finger protein 575

      See identical proteins and their annotated locations for NP_777605.1

      Status: VALIDATED

      Source sequence(s)
      AC018758
      Consensus CDS
      CCDS12623.1
      UniProtKB/Swiss-Prot
      B4DX54, Q86XF7
      Related
      ENSP00000315870.4, ENST00000314228.10
      Conserved Domains (2) summary
      PHA03247
      Location:6 → 211
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:93 → 113
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43530835..43536087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526793.4 → XP_011525095.1  zinc finger protein 575 isoform X1

      See identical proteins and their annotated locations for XP_011525095.1

      UniProtKB/Swiss-Prot
      B4DX54, Q86XF7
      Conserved Domains (2) summary
      PHA03247
      Location:6 → 211
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:93 → 113
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_047438637.1 → XP_047294593.1  zinc finger protein 575 isoform X1

      UniProtKB/Swiss-Prot
      B4DX54, Q86XF7
      Related
      ENSP00000471083.2, ENST00000598080.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46352369..46357622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320626.1 → XP_054176601.1  zinc finger protein 575 isoform X1

      UniProtKB/Swiss-Prot
      B4DX54, Q86XF7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XF7.1 GenPept UniProtKB/Swiss-Prot:Q86XF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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