U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZNF682 zinc finger protein 682 [ Homo sapiens (human) ]

    Gene ID: 91120, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZNF682provided by HGNC
    Official Full Name
    zinc finger protein 682provided by HGNC
    Primary source
    HGNC:HGNC:28857
    See related
    Ensembl:ENSG00000197124 AllianceGenome:HGNC:28857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BC39498_3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.3), skin (RPKM 2.1) and 23 other tissues See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZNF682 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19995131..20039505, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (20142143..20177228, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (20115227..20150314, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904665 Neighboring gene BCL2 interacting protein 3 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 9515 Neighboring gene vomeronasal 1 receptor 77 pseudogene Neighboring gene uncharacterized LOC105372308 Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20150084-20150660 Neighboring gene uncharacterized LOC105372309 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20162158-20162885 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20162886-20163612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:20169525-20170470 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:20170471-20171415 Neighboring gene BCL2 interacting protein 3 pseudogene 13

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    2. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ90362

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 682

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077349.1 → NP_001070817.1  zinc finger protein 682 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006539, AK098164, DB174863
      Consensus CDS
      CCDS42534.1
      UniProtKB/TrEMBL
      B3KUX2
      Related
      ENSP00000380348.1, ENST00000397162.5
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:207 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:183 → 207
      zf-H2C2_2; Zinc-finger double domain

    2. NM_033196.3 → NP_149973.1  zinc finger protein 682 isoform 1

      See identical proteins and their annotated locations for NP_149973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC006539, DA612976, DA788529, DR002650
      Consensus CDS
      CCDS42533.1
      UniProtKB/Swiss-Prot
      B3KU64, E9PFJ5, O95780, Q96JV9
      Related
      ENSP00000380351.1, ENST00000397165.7
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:239 → 445
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:371 → 391
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:215 → 239
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      19995131..20039505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439655.1 → XP_047295611.1  zinc finger protein 682 isoform X1

    2. XM_047439657.1 → XP_047295613.1  zinc finger protein 682 isoform X2

    3. XM_047439658.1 → XP_047295614.1  zinc finger protein 682 isoform X2

    4. XM_047439656.1 → XP_047295612.1  zinc finger protein 682 isoform X2

      Related
      ENSP00000471717.1, ENST00000595736.1

    RNA

    1. XR_007067033.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      20142143..20177228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322560.1 → XP_054178535.1  zinc finger protein 682 isoform X1

    2. XM_054322561.1 → XP_054178536.1  zinc finger protein 682 isoform X1

    3. XM_054322563.1 → XP_054178538.1  zinc finger protein 682 isoform X2

    4. XM_054322564.1 → XP_054178539.1  zinc finger protein 682 isoform X2

    5. XM_054322562.1 → XP_054178537.1  zinc finger protein 682 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95780.1 GenPept UniProtKB/Swiss-Prot:O95780

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous