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    WDCP WD repeat and coiled coil containing [ Homo sapiens (human) ]

    Gene ID: 80304, updated on 28-Oct-2024

    Summary

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    Official Symbol
    WDCPprovided by HGNC
    Official Full Name
    WD repeat and coiled coil containingprovided by HGNC
    Primary source
    HGNC:HGNC:26157
    See related
    Ensembl:ENSG00000163026 MIM:616234; AllianceGenome:HGNC:26157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMAP; PP384; C2orf44
    Summary
    Enables kinase binding activity. Involved in protein complex oligomerization. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WDCP in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24029347..24047391, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24064045..24082083, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24252217..24270261, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UBX domain protein 2A Neighboring gene RNA, 7SL, cytoplasmic 610, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24238941-24239496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24239497-24240052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:24244092-24244708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24246333-24247318 Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11225 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:24276709-24276900 Neighboring gene FKBP prolyl isomerase 1B Neighboring gene Sharpr-MPRA regulatory region 5215 Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:24298482-24299014 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:24299015-24299546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24305416-24306346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11227 Neighboring gene splicing factor 3b subunit 6 Neighboring gene family with sequence similarity 228 member B Neighboring gene tumor protein p53 inducible protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Xu R, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30297404, Free PMC Article
    2. Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK. Yokoyama N, et al. Biomed Rep, 2015 Jan. PMID 25469238, Free PMC Article
    3. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Lipson D, et al. Nat Med, 2012 Feb 12. PMID 22327622, Free PMC Article
    4. Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Sardiu ME, et al. Proc Natl Acad Sci U S A, 2008 Feb 5. PMID 18218781, Free PMC Article
    5. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. Scott MP, et al. J Biol Chem, 2002 Aug 2. PMID 12029088

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21945

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat and coiled-coil-containing protein
    Names
    WD repeat and coiled-coil-containing protein C2orf44
    WD repeat-containing protein C2orf44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142319.2 → NP_001135791.1  WD repeat and coiled-coil-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001135791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI800484, AK025598, BC035698, DB292134
      Consensus CDS
      CCDS46229.1
      UniProtKB/Swiss-Prot
      Q9H6R7
      Related
      ENSP00000385816.3, ENST00000406895.3
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 608
      DUF4613; Domain of unknown function (DUF4613)

    2. NM_025203.3 → NP_079479.1  WD repeat and coiled-coil-containing protein isoform 1

      See identical proteins and their annotated locations for NP_079479.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK025598, BC035698, CX756689, DB292134
      Consensus CDS
      CCDS1705.1
      UniProtKB/Swiss-Prot
      D6W532, Q8IYK0, Q9H6R7, Q9HBP5
      Related
      ENSP00000295148.4, ENST00000295148.9
      Conserved Domains (1) summary
      pfam15390
      Location:2 → 672
      DUF4613; Domain of unknown function (DUF4613)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24029347..24047391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24064045..24082083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H6R7.1 GenPept UniProtKB/Swiss-Prot:Q9H6R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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