APOM apolipoprotein M [Homo sapiens (human)] - Gene

Summary

Official Symbol: APOMprovided by HGNC
Official Full Name: apolipoprotein Mprovided by HGNC
Primary source: HGNC:HGNC:13916
See related: Ensembl:ENSG00000204444 MIM:606907; AllianceGenome:HGNC:13916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: G3a; NG20; apo-M; HSPC336
Summary: The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
Expression: Biased expression in liver (RPKM 122.3), kidney (RPKM 73.7) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (31652404..31658210)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (31505437..31511243)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (31620181..31625987)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma apolipoprotein M predicts overall survival in metastatic breast cancer patients.
Title: Plasma apolipoprotein M predicts overall survival in metastatic breast cancer patients.
ApoM suppresses kidney renal clear cell carcinoma growth and metastasis via the Hippo-YAP signaling pathway.
Title: ApoM suppresses kidney renal clear cell carcinoma growth and metastasis via the Hippo-YAP signaling pathway.
Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans.
Title: Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans.
Regulation of the apolipoprotein M signaling pathway: a review.
Title: Regulation of the apolipoprotein M signaling pathway: a review.
The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells.
Title: The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells.
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Title: Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Apolipoprotein M Gene Polymorphism Rs805297 (C-1065A): Association With Type 2 Diabetes Mellitus and Related Microvascular Complications in South Egypt.
Title: Apolipoprotein M Gene Polymorphism Rs805297 (C-1065A): Association With Type 2 Diabetes Mellitus and Related Microvascular Complications in South Egypt.
Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
Title: Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
Title: Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein.
Title: Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein.

Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common 5p15.33 and 6p21.33 variants influence lung cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92454 (e-PCR)
- UniSTS:90437

RH122245 (e-PCR)
- UniSTS:134793

A007I39 (e-PCR)
- UniSTS:63195

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables antioxidant activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IC Inferred by Curator more info	PubMed
involved_in high-density lipoprotein particle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in high-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasma lipoprotein oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in reverse cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of discoidal high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of spherical high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: apolipoprotein M

Names: NG20-like protein; alternative name: G3a, NG20; protein G3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256169.2 → NP_001243098.1 apolipoprotein M isoform 2

See identical proteins and their annotated locations for NP_001243098.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA476324, AL662801, CB054016, CN428415

Consensus CDS

CCDS59004.1

UniProtKB/TrEMBL

A0A1U9X793, Q5SRP5

Related

ENSP00000365085.4, ENST00000375920.8

Conserved Domains (1) summary

cl21528
Location:1 → 115

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_019101.3 → NP_061974.2 apolipoprotein M isoform 1

See identical proteins and their annotated locations for NP_061974.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AL662801

Consensus CDS

CCDS4710.1

UniProtKB/Swiss-Prot

B0UX98, O95445, Q5SRP4, Q9P046, Q9UMP6

Related

ENSP00000365081.3, ENST00000375916.4

Conserved Domains (1) summary

cl21528
Location:1 → 187

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

NR_045828.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, found in variant 1.

Source sequence(s)

AA846749, AL662801, BF344944, CB054016