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    iss1 fip1-like pre-mRNA polyadenylation factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541873, updated on 18-Sep-2024

    Summary

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    Official Symbol
    iss1
    Official Full Name
    fip1-like pre-mRNA polyadenylation factor
    Primary source
    PomBase:SPAC22G7.10
    Locus tag
    SPOM_SPAC22G7.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See iss1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (753671..755676)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene nucleoporin Nup45 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein cum1 Neighboring gene ncRNA Neighboring gene translocon gamma subunit Sss1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation. Lee SY, et al. Cell Rep, 2020 Feb 25. PMID 32101745, Free PMC Article
    2. A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts. Yamashita A, et al. Nucleic Acids Res, 2013 Nov. PMID 23980030, Free PMC Article
    3. CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing. Vo TV, et al. Cell Rep, 2019 Jul 2. PMID 31269446, Free PMC Article
    4. A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Roguev A, et al. Mol Cell Proteomics, 2004 Feb. PMID 14617822
    5. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in heterochromatin island IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear exosome focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    fip1-like pre-mRNA polyadenylation factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      753671..755676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018457.3 → NP_593059.1  fip1-like pre-mRNA polyadenylation factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593059.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09801
      Conserved Domains (1) summary
      COG5213
      Location:1 → 271
      FIP1; Polyadenylation factor I complex, subunit FIP1 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version

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