U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    isa1 Fe-sulfur protein Isa1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539409, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    isa1
    Official Full Name
    Fe-sulfur protein Isa1
    Primary source
    PomBase:SPCC645.03c
    Locus tag
    SPOM_SPCC645.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See isa1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1230674..1231856, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G1/S-specific B-type cyclin Cig1 Neighboring gene cardiolipin synthase PGP phosphatase domain-containing Gep4 Neighboring gene ncRNA Neighboring gene Smc5-6 complex non-SMC MAGE family subunit Nse3 Neighboring gene myosin II heavy chain myo2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking. Fidai I, et al. J Biol Inorg Chem, 2016 Oct. PMID 27590019
    2. Iron-sulfur cluster biosynthesis. A comparative kinetic analysis of native and Cys-substituted ISA-mediated [2Fe-2S]2+ cluster transfer to an apoferredoxin target. Wu SP, et al. Biochemistry, 2003 May 20. PMID 12741836
    3. Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. Brancaccio D, et al. J Am Chem Soc, 2014 Nov 19. PMID 25347204
    4. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20085751
    5. Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism. Shi R, et al. Front Cell Dev Biol, 2021. PMID 34660592, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that Grx5 plays a central role in Fe-S assembly process through interaction with A-type Fe-S scaffold proteins Isa1 and Isa2.
      Title: Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in [4Fe-4S] cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial [4Fe-4S] assembly complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Fe-sulfur protein Isa1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1230674..1231856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023102.3 → NP_588112.1  Fe-sulfur protein Isa1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588112.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78859
      Conserved Domains (1) summary
      TIGR00049
      Location:84 → 188
      TIGR00049; Iron-sulfur cluster assembly accessory protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous