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    maf1 RNA polymerase III-inhibiting protein Maf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542394, updated on 18-Sep-2024

    Summary

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    Official Symbol
    maf1
    Official Full Name
    RNA polymerase III-inhibiting protein Maf1
    Primary source
    PomBase:SPAC31G5.12c
    Locus tag
    SPOM_SPAC31G5.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    n150
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    Genomic context

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    See maf1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3007584..3009378, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA polymerase I termination factor, Myb family Eta2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cAMP-independent regulatory protein Pac2 Neighboring gene ncRNA Neighboring gene FAM32A family protein Neighboring gene ncRNA Neighboring gene 19S proteasome regulatory subunit, ubiquitin-specific protease subunit Rpn11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan. Noguchi C, et al. Cell Cycle, 2021 Feb. PMID 33475456, Free PMC Article
    2. Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo. Rijal K, et al. PLoS Genet, 2016 Aug. PMID 27518095, Free PMC Article
    3. Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan. Shetty M, et al. Aging Cell, 2020 Feb. PMID 31833215, Free PMC Article
    4. RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification. Arimbasseri AG, et al. PLoS Genet, 2015 Dec. PMID 26720005, Free PMC Article
    5. Two steps in Maf1-dependent repression of transcription by RNA polymerase III. Desai N, et al. J Biol Chem, 2005 Feb 25. PMID 15590667

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan.
      Title: Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan.
    2. Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.
      Title: Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.
    3. By ruling out differences in RNA decay rates, the data indicate that mutants with the RT phenotype synthesize more RNA than wild type cells, and than can be accounted for by their increased elongation rate. Finally, increased activity by the mutants appears unrelated to the RNAP III repressor, Maf1
      Title: Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo.
    4. Maf1 is a rapamycin-sensitive regulator of RNAP III-mediated tRNA transcription in S. pombe.
      Title: RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase III-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables RNA polymerase III core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase III EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase III-inhibiting protein Maf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3007584..3009378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019438.4 → NP_594012.2  RNA polymerase III-inhibiting protein Maf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594012.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14109, Q92362
      Conserved Domains (1) summary
      COG5046
      Location:35 → 238
      MAF1; Protein involved in Mod5 protein sorting [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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