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    urk1 uridine kinase/uracil phosphoribosyltransferase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538946, updated on 18-Sep-2024

    Summary

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    Official Symbol
    urk1
    Official Full Name
    uridine kinase/uracil phosphoribosyltransferase
    Primary source
    PomBase:SPCC162.11c
    Locus tag
    SPOM_SPCC162.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See urk1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1555999..1557913)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene zinc finger C3HC-type containing RNA export factor Rsm1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TORC1 subunit Tco89 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk33 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase Hmg1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. Kriegenburg F, et al. PLoS Genet, 2014 Jan. PMID 24497846, Free PMC Article
    2. Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast. Navarro FJ, et al. J Cell Sci, 2017 Dec 15. PMID 29084823, Free PMC Article
    3. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
    4. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil phosphoribosyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables uridine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase metabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in pyrimidine-containing compound salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    uridine kinase/uracil phosphoribosyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1555999..1557913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355921.2 → NP_001342737.1  uridine kinase/uracil phosphoribosyltransferase [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74427
      Conserved Domains (2) summary
      COG0035
      Location:250 → 454
      Upp; Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]
      cd02023
      Location:23 → 220
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    Nucleotide Protein
    Heading Accession and Version

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