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    PPIG peptidylprolyl isomerase G [ Homo sapiens (human) ]

    Gene ID: 9360, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PPIGprovided by HGNC
    Official Full Name
    peptidylprolyl isomerase Gprovided by HGNC
    Primary source
    HGNC:HGNC:14650
    See related
    Ensembl:ENSG00000138398 MIM:606093; AllianceGenome:HGNC:14650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYP; SRCyp; SCAF10; CARS-Cyp
    Summary
    Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.9), endometrium (RPKM 11.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPIG in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169584351..169641406)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170060945..170118571)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170440861..170497916)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 41 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:170393950-170394098 Neighboring gene FAST kinase domains 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:170429982-170430584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16741 Neighboring gene MPRA-validated peak3919 silencer Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene cilia and flagella associated protein 210 Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene phosphatase, orphan 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RS cyclophilins: identification of an NK-TR1-related cyclophilin. Nestel FP, et al. Gene, 1996 Nov 21. PMID 8973360
    2. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. Lin CL, et al. Biochem Biophys Res Commun, 2004 Aug 27. PMID 15358154
    3. Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin. Szlavicz E, et al. Mol Cell Biochem, 2017 Dec. PMID 28589370
    4. Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells. Nakamura K, et al. Sci Rep, 2017 Jan 23. PMID 28112215, Free PMC Article
    5. The human nuclear SRcyp is a cell cycle-regulated cyclophilin. Dubourg B, et al. J Biol Chem, 2004 May 21. PMID 15016823

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The finding that zebularine upregulates CYP gene expression through DNMT1 and PKR modulation sheds light on the mechanisms controlling hepatocyte function and thus may aid in the development of new in-vitro systems using high-functioning hepatocytes
      Title: Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells.
    2. results indicate that LUC7L3, PPIG, and SFRS18 are not only implicated in EDA+ fibronectin formation, but also that they could possess multiple roles in psoriasis-associated molecular abnormalities.
      Title: Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.
    4. Results show that SR-cyclophilin interacts and colocalizes with nuclear pinin, a SR-related protein involved in pre-mRNA splicing.
      Title: Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.
    5. human nuclear SRcyp is a cell cycle-regulated cyclophilin
      Title: The human nuclear SRcyp is a cell cycle-regulated cyclophilin.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat downregulates the abundance of peptidylprolyl isomerase G (PPIG, cyclophilin G) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133241

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase G
    Names
    CARS-cyclophilin
    CASP10
    Clk-associating RS-cyclophilin
    PPIase G
    SR-cyclophilin
    SR-cyp
    SR-related CTD-associated factor 10
    cyclophilin G
    peptidyl-prolyl isomerase G (cyclophilin G)
    rotamase G
    NP_004783.2
    XP_005247023.1
    XP_005247024.1
    XP_016860791.1
    XP_054200604.1
    XP_054200605.1
    XP_054200606.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004792.3 → NP_004783.2  peptidyl-prolyl cis-trans isomerase G

      See identical proteins and their annotated locations for NP_004783.2

      Status: VALIDATED

      Source sequence(s)
      AC016772, BG615922, CA418130, X99717
      Consensus CDS
      CCDS2235.1
      UniProtKB/Swiss-Prot
      D3DPC5, D3DPC6, O00706, Q13427, Q53R40, Q53SN4, Q96DG9
      UniProtKB/TrEMBL
      A0A7I2V5Q5
      Related
      ENSP00000260970.3, ENST00000260970.8
      Conserved Domains (2) summary
      PTZ00121
      Location:392 → 752
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8 → 175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      169584351..169641406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246967.2 → XP_005247024.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      See identical proteins and their annotated locations for XP_005247024.1

      UniProtKB/Swiss-Prot
      D3DPC5, D3DPC6, O00706, Q13427, Q53R40, Q53SN4, Q96DG9
      UniProtKB/TrEMBL
      A0A7I2V5Q5
      Related
      ENSP00000503525.1, ENST00000676756.1
      Conserved Domains (2) summary
      PTZ00121
      Location:392 → 752
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8 → 175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    2. XM_017005302.3 → XP_016860791.1  peptidyl-prolyl cis-trans isomerase G isoform X2

    3. XM_005246966.3 → XP_005247023.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      See identical proteins and their annotated locations for XP_005247023.1

      UniProtKB/Swiss-Prot
      D3DPC5, D3DPC6, O00706, Q13427, Q53R40, Q53SN4, Q96DG9
      UniProtKB/TrEMBL
      A0A7I2V5Q5
      Related
      ENSP00000503136.1, ENST00000678499.1
      Conserved Domains (2) summary
      PTZ00121
      Location:392 → 752
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8 → 175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      170060945..170118571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344630.1 → XP_054200605.1  peptidyl-prolyl cis-trans isomerase G isoform X1

    2. XM_054344631.1 → XP_054200606.1  peptidyl-prolyl cis-trans isomerase G isoform X2

    3. XM_054344629.1 → XP_054200604.1  peptidyl-prolyl cis-trans isomerase G isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13427.2 GenPept UniProtKB/Swiss-Prot:Q13427

    Gene LinkOut

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