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    TMEM150A transmembrane protein 150A [ Homo sapiens (human) ]

    Gene ID: 129303, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM150Aprovided by HGNC
    Official Full Name
    transmembrane protein 150Aprovided by HGNC
    Primary source
    HGNC:HGNC:24677
    See related
    Ensembl:ENSG00000168890 MIM:616757; AllianceGenome:HGNC:24677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTN1; TM6P1; TMEM150
    Summary
    Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 10.3), kidney (RPKM 7.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM150A in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85598547..85602698, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85600607..85604758, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85825670..85829821, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85811231-85812186 Neighboring gene vesicle associated membrane protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85819815-85820316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85820317-85820816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11705 Neighboring gene ring finger protein 181 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene chromosome 2 open reading frame 68 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85838960-85839341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16134 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85839517-85839689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16136 Neighboring gene surfactant protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses. Fan ST, et al. PLoS One, 2023. PMID 38055673, Free PMC Article
    2. Identification of a new gene (rat TM6P1) encoding a fasting-inducible, integral membrane protein with six transmembrane domains. Zhang J, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858565
    3. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. Hong GS, et al. Neuron, 2016 Jul 6. PMID 27321926
    4. Plasticity of PI4KIIIα interactions at the plasma membrane. Chung J, et al. EMBO Rep, 2015 Mar. PMID 25608530, Free PMC Article
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses.
      Title: Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses.
    2. TMEM150A is a functional homologue of Sfk1 in mammalian cells and plays a role in the homeostatic regulation of PI(4,5)P2 at the plasma membrane.
      Title: Plasticity of PI4KIIIα interactions at the plasma membrane.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90024

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 150A
    Names
    fasting-inducible integral membrane protein TM6P1
    tentonin 1
    transmembrane protein 150

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031738.3 → NP_001026908.1  transmembrane protein 150A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001026908.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AW009533, BC050466, DA434376
      Consensus CDS
      CCDS33233.1
      UniProtKB/Swiss-Prot
      A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
      Related
      ENSP00000334708.5, ENST00000334462.10
      Conserved Domains (1) summary
      pfam10277
      Location:3 → 229
      Frag1; Frag1/DRAM/Sfk1 family

    2. NM_001369917.1 → NP_001356846.1  transmembrane protein 150A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC016753
      Consensus CDS
      CCDS33233.1
      UniProtKB/Swiss-Prot
      A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
      Related
      ENSP00000387292.1, ENST00000409668.1
      Conserved Domains (1) summary
      pfam10277
      Location:3 → 229
      Frag1; Frag1/DRAM/Sfk1 family

    3. NM_153342.4 → NP_699173.2  transmembrane protein 150A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC016753
      Consensus CDS
      CCDS1982.1
      Related
      ENSP00000302715.3, ENST00000306353.7
      Conserved Domains (1) summary
      pfam10277
      Location:37 → 176
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      85598547..85602698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711931.4 → XP_006711994.1  transmembrane protein 150A isoform X1

      See identical proteins and their annotated locations for XP_006711994.1

      UniProtKB/Swiss-Prot
      A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
      Conserved Domains (1) summary
      pfam10277
      Location:3 → 229
      Frag1; Frag1/DRAM/Sfk1 family

    2. XM_047443258.1 → XP_047299214.1  transmembrane protein 150A isoform X4

    3. XM_006711930.4 → XP_006711993.1  transmembrane protein 150A isoform X1

      See identical proteins and their annotated locations for XP_006711993.1

      UniProtKB/Swiss-Prot
      A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
      Conserved Domains (1) summary
      pfam10277
      Location:3 → 229
      Frag1; Frag1/DRAM/Sfk1 family

    4. XM_011532508.3 → XP_011530810.1  transmembrane protein 150A isoform X4

      See identical proteins and their annotated locations for XP_011530810.1

      UniProtKB/Swiss-Prot
      Q86TG1
      Conserved Domains (1) summary
      pfam10277
      Location:37 → 176
      Frag1; Frag1/DRAM/Sfk1 family

    5. XM_011532505.3 → XP_011530807.1  transmembrane protein 150A isoform X2

      Conserved Domains (1) summary
      pfam10277
      Location:1 → 205
      Frag1; Frag1/DRAM/Sfk1 family

    6. XM_047443265.1 → XP_047299221.1  transmembrane protein 150A isoform X5

    7. XM_011532507.3 → XP_011530809.1  transmembrane protein 150A isoform X3

      See identical proteins and their annotated locations for XP_011530809.1

      Conserved Domains (1) summary
      pfam10277
      Location:20 → 182
      Frag1; Frag1/DRAM/Sfk1 family

    8. XM_017003305.2 → XP_016858794.1  transmembrane protein 150A isoform X3

      Conserved Domains (1) summary
      pfam10277
      Location:20 → 182
      Frag1; Frag1/DRAM/Sfk1 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      85600607..85604758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340463.1 → XP_054196438.1  transmembrane protein 150A isoform X1

      UniProtKB/Swiss-Prot
      A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6

    2. XM_054340468.1 → XP_054196443.1  transmembrane protein 150A isoform X4

    3. XM_054340464.1 → XP_054196439.1  transmembrane protein 150A isoform X1

      UniProtKB/Swiss-Prot
      A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6

    4. XM_054340469.1 → XP_054196444.1  transmembrane protein 150A isoform X4

    5. XM_054340465.1 → XP_054196440.1  transmembrane protein 150A isoform X2

    6. XM_054340470.1 → XP_054196445.1  transmembrane protein 150A isoform X5

    7. XM_054340467.1 → XP_054196442.1  transmembrane protein 150A isoform X3

    8. XM_054340466.1 → XP_054196441.1  transmembrane protein 150A isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86TG1.1 GenPept UniProtKB/Swiss-Prot:Q86TG1

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