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    Kif12 kinesin family member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313254, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Kif12provided by RGD
    Official Full Name
    kinesin family member 12provided by RGD
    Primary source
    RGD:1308487
    See related
    EnsemblRapid:ENSRNOG00000007080 AllianceGenome:RGD:1308487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in extracellular exosome and microtubule organizing center. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward (RPKM 736.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif12 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81611730..81620977, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76596204..76603261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (79001708..79008370, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 618 Neighboring gene alpha-1-microglobulin/bikunin precursor Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455 Neighboring gene orosomucoid 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. Courtois A, et al. J Cell Biol, 2012 Aug 6. PMID 22851319, Free PMC Article
    2. Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Zhang Y, et al. Electrophoresis, 2010 Dec. PMID 21082674
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012102.2 → NP_001012102.2  kinesin-like protein KIF12

      See identical proteins and their annotated locations for NP_001012102.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6J7X5
      Conserved Domains (3) summary
      cd00106
      Location:25 → 363
      KISc; Kinesin motor domain
      pfam00225
      Location:31 → 365
      Kinesin; Kinesin motor domain
      pfam12711
      Location:384 → 469
      Kinesin-relat_1; Kinesin motor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      81611730..81620977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238253.5 → XP_006238315.1  kinesin-like protein KIF12 isoform X1

      UniProtKB/TrEMBL
      G3V6Y3
      Related
      ENSRNOP00000010040.5, ENSRNOT00000010040.7
      Conserved Domains (3) summary
      cd00106
      Location:25 → 363
      KISc; Kinesin motor domain
      pfam00225
      Location:31 → 365
      Kinesin; Kinesin motor domain
      pfam12711
      Location:384 → 469
      Kinesin-relat_1; Kinesin motor

    2. XM_063287632.1 → XP_063143702.1  kinesin-like protein KIF12 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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