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    PIGR polymeric immunoglobulin receptor [ Homo sapiens (human) ]

    Gene ID: 5284, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PIGRprovided by HGNC
    Official Full Name
    polymeric immunoglobulin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:8968
    See related
    Ensembl:ENSG00000162896 MIM:173880; AllianceGenome:HGNC:8968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
    Expression
    Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PIGR in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206928522..206946466, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206193722..206211683, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207101867..207119811, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:207078063-207079262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene interleukin 24 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. In vitro refolding of recombinant human free secretory component using equilibrium gradient dialysis. Prinsloo E, et al. Protein Expr Purif, 2006 May. PMID 16288892
    2. The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor. Braathen R, et al. J Biol Chem, 2002 Nov 8. PMID 12213814
    3. Secretory component is cleaved by neutrophil serine proteinases but its epithelial production is increased by neutrophils through NF-kappa B- and p38 mitogen-activated protein kinase-dependent mechanisms. Pilette C, et al. Am J Respir Cell Mol Biol, 2003 Apr. PMID 12654638
    4. Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients. Obara W, et al. J Hum Genet, 2003. PMID 12740691
    5. The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. Lu L, et al. J Biol Chem, 2003 Nov 28. PMID 13679368

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
      Title: SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
    2. Polymeric immunoglobulin receptor (pIgR) in cancer.
      Title: Polymeric immunoglobulin receptor (pIgR) in cancer.
    3. Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
      Title: Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
    4. Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
      Title: Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
    5. Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
      Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
    6. M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1beta.
      Title: M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.
    7. Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
      Title: Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
    8. Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
      Title: Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
    9. A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.
      Title: A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.
    10. High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.
      Title: High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22667, MGC125361, MGC125362

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables polymeric immunoglobulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polymeric immunoglobulin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor clustering IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of secretory IgA immunoglobulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polymeric immunoglobulin receptor
    Names
    hepatocellular carcinoma associated protein TB6
    poly-Ig receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012927.1 RefSeqGene

      Range
      5001..22945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002644.4 → NP_002635.2  polymeric immunoglobulin receptor precursor

      See identical proteins and their annotated locations for NP_002635.2

      Status: REVIEWED

      Source sequence(s)
      AF272149, AK225471
      Consensus CDS
      CCDS1474.1
      UniProtKB/Swiss-Prot
      P01833, Q68D81, Q8IZY7
      Related
      ENSP00000348888.4, ENST00000356495.5
      Conserved Domains (1) summary
      cd05716
      Location:464 → 560
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206928522..206946466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509629.2 → XP_011507931.1  polymeric immunoglobulin receptor isoform X1

      See identical proteins and their annotated locations for XP_011507931.1

      UniProtKB/Swiss-Prot
      P01833, Q68D81, Q8IZY7
      Conserved Domains (1) summary
      cd05716
      Location:464 → 560
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206193722..206211683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337031.1 → XP_054193006.1  polymeric immunoglobulin receptor isoform X1

      UniProtKB/Swiss-Prot
      P01833, Q68D81, Q8IZY7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01833.4 GenPept UniProtKB/Swiss-Prot:P01833

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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