OPRPN opiorphin prepropeptide [Homo sapiens (human)] - Gene

Summary

Official Symbol: OPRPNprovided by HGNC
Official Full Name: opiorphin prepropeptideprovided by HGNC
Primary source: HGNC:HGNC:17279
See related: Ensembl:ENSG00000171199 MIM:608936; AllianceGenome:HGNC:17279
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BPLP; PRL1; PROL1; opiorphin
Summary: This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression: Restricted expression toward salivary gland (RPKM 9.7) See more
Orthologs: all
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Genomic context

Location:: 4q13.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (70397940..70410195)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (73737473..73749728)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (71263657..71275912)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Relationship between saliva opiorphin levels, pain threshold, and cutting number in adolescents with non suicidal self injury.
Title: Relationship between saliva opiorphin levels, pain threshold, and cutting number in adolescents with non suicidal self injury.
Role of opiorphin genes in prostate cancer growth and progression.
Title: Role of opiorphin genes in prostate cancer growth and progression.
All members of the human opiorphin family of genes can potentially modulate erectile physiology. Both hSMR3 and ProL1 are down-regulated in the corpora of men with ED, and therefore both genes can potentially act as markers of ED.
Title: The opiorphin gene (ProL1) and its homologues function in erectile physiology.
Results report the discovery of opiorphin, a previously uncharacterized physiological inhibitor of enkephalin-inactivating zinc ectopeptidases in humans.
Title: Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67981 (e-PCR)
- UniSTS:9245

NoName (e-PCR)
- UniSTS:495235

NoName (e-PCR)
- UniSTS:486799

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed

General protein information

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Preferred Names: opiorphin prepropeptide

Names: basic proline-rich lacrimal protein; basic proline-rich protein; proline rich, lacrimal 1; proline-rich 1; proline-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302807.2 → NP_001289736.1 opiorphin prepropeptide isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) lacks the functional QRFSR pentapeptide, known as opiorphin, located in the N-terminal of isoform 1.

Source sequence(s)

CD721906, CD722615, CD723077

Conserved Domains (2) summary

pfam14124
Location:1 → 55

DUF4291; Domain of unknown function (DUF4291)

pfam15621
Location:1 → 18

PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
NM_021225.5 → NP_067048.4 opiorphin prepropeptide isoform 1 precursor

See identical proteins and their annotated locations for NP_067048.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC092438, CK430664

Consensus CDS

CCDS43235.1

UniProtKB/Swiss-Prot

A8MZ07, P85047, Q99935

Related

ENSP00000382485.2, ENST00000399575.7

Conserved Domains (1) summary

pfam15621
Location:3 → 96

PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

RNA

NR_126503.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

CD721906, CD722615, CK429697