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    Phyhip phytanoyl-CoA hydroxylase interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 105653, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Phyhipprovided by MGI
    Official Full Name
    phytanoyl-CoA hydroxylase interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1860417
    See related
    Ensembl:ENSMUSG00000003469 AllianceGenome:MGI:1860417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lnap1ip; PAHX-AP1; PAHX-AP#1; C630010D02Rik
    Summary
    Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; hemolymphoid system gland; musculoskeletal system; nose; and skin. Orthologous to human PHYHIP (phytanoyl-CoA 2-hydroxylase interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 89.9), cortex adult (RPKM 83.2) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phyhip in Genome Data Viewer
    Location:
    14 D2; 14 36.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70694957..70706266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70457517..70468826)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:70842927-70843227 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide D Neighboring gene microRNA 320 Neighboring gene STARR-positive B cell enhancer ABC_E7332 Neighboring gene bone morphogenetic protein 1 Neighboring gene predicted gene, 52136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70920317-70920426 Neighboring gene surfactant associated protein C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiac Characteristics of Transgenic Mice Overexpressing Refsum Disease Gene-Associated Protein within the Heart. Koh JT, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527414
    2. Changes underlying arrhythmia in the transgenic heart overexpressing Refsum disease gene-associated protein. Koh JT, et al. Biochem Biophys Res Commun, 2004 Jan 2. PMID 14672712
    3. Identification of a brain specific protein that associates with a refsum disease gene product, phytanoyl-CoA alpha-hydroxylase. Lee ZH, et al. Brain Res Mol Brain Res, 2000 Feb 22. PMID 10686344
    4. Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. Koh JT, et al. Brain Res Mol Brain Res, 2001 Mar 5. PMID 11245925
    5. Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study. Raspa M, et al. Theriogenology, 2017 Jul 1. PMID 28532839

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40960

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phytanoyl-CoA hydroxylase-interacting protein
    Names
    PAHXAP1
    lupus nephritis-associated peptide 1 interacting protein
    phytanoyl-CoA hydroxylase-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145981.3 → NP_666093.1  phytanoyl-CoA hydroxylase-interacting protein

      See identical proteins and their annotated locations for NP_666093.1

      Status: PROVISIONAL

      Source sequence(s)
      AK049900
      Consensus CDS
      CCDS36971.1
      UniProtKB/Swiss-Prot
      Q8K0S0
      UniProtKB/TrEMBL
      B9EIC7
      Related
      ENSMUSP00000003561.4, ENSMUST00000003561.10
      Conserved Domains (1) summary
      cd00063
      Location:5 → 112
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70694957..70706266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518379.5 → XP_006518442.1  phytanoyl-CoA hydroxylase-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006518442.1

      UniProtKB/Swiss-Prot
      Q8K0S0
      UniProtKB/TrEMBL
      B9EIC7
      Conserved Domains (1) summary
      cd00063
      Location:5 → 112
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_006518380.4 → XP_006518443.1  phytanoyl-CoA hydroxylase-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006518443.1

      UniProtKB/Swiss-Prot
      Q8K0S0
      UniProtKB/TrEMBL
      B9EIC7
      Conserved Domains (1) summary
      cd00063
      Location:5 → 112
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0S0.1 GenPept UniProtKB/Swiss-Prot:Q8K0S0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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