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    Rhobtb1 Rho-related BTB domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 69288, updated on 2-Nov-2024

    Summary

    Official Symbol
    Rhobtb1provided by MGI
    Official Full Name
    Rho-related BTB domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916538
    See related
    Ensembl:ENSMUSG00000019944 AllianceGenome:MGI:1916538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700008H16Rik; 3110048G13Rik
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and stomach. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 5.9), ovary adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rhobtb1 in Genome Data Viewer
    Location:
    10 B5.3; 10 36.04 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (68987106..69127621)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (69151058..69291791)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24172 Neighboring gene predicted gene, 33263 Neighboring gene STARR-positive B cell enhancer ABC_E8862 Neighboring gene RIKEN cDNA A930033H14 gene Neighboring gene predicted gene, 40685 Neighboring gene ribosomal protein L30, pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107538

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    rho-related BTB domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081347.1NP_001074816.1  rho-related BTB domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001074816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC117209
      Consensus CDS
      CCDS35930.1
      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Related
      ENSMUSP00000020101.6, ENSMUST00000020101.12
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    2. NM_001252636.1NP_001239565.1  rho-related BTB domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239565.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC117209, AK005770
      Consensus CDS
      CCDS35930.1
      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Related
      ENSMUSP00000132068.2, ENSMUST00000164034.8
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    3. NM_001252637.1NP_001239566.1  rho-related BTB domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC117209, BB611014, BC137646
      Consensus CDS
      CCDS35930.1
      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Related
      ENSMUSP00000065095.8, ENSMUST00000067908.14
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    4. NM_001252638.1NP_001239567.1  rho-related BTB domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001239567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC117209, BC144800
      UniProtKB/TrEMBL
      B7ZMU4, Q6A003
      Conserved Domains (3) summary
      cd18530
      Location:472571
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:344469
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:187
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      68987106..69127621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514049.5XP_006514112.1  rho-related BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514112.1

      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    2. XM_006514048.5XP_006514111.1  rho-related BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514111.1

      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    3. XM_036155982.1XP_036011875.1  rho-related BTB domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    4. XM_006514051.5XP_006514114.1  rho-related BTB domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514114.1

      UniProtKB/Swiss-Prot
      B2RPX3, Q9DAK3
      UniProtKB/TrEMBL
      Q499C9
      Conserved Domains (3) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18530
      Location:592691
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:464589
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    5. XM_006514054.2XP_006514117.1  rho-related BTB domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006514117.1

      UniProtKB/TrEMBL
      B7ZMU4, Q6A003
      Conserved Domains (3) summary
      cd18530
      Location:472571
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:344469
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:187
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. XM_006514052.5XP_006514115.1  rho-related BTB domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006514115.1

      UniProtKB/TrEMBL
      B7ZMU4, Q6A003
      Conserved Domains (3) summary
      cd18530
      Location:472571
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:344469
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:187
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    7. XM_006514053.5XP_006514116.1  rho-related BTB domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006514116.1

      UniProtKB/TrEMBL
      B7ZMU4, Q6A003
      Conserved Domains (3) summary
      cd18530
      Location:472571
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:344469
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:187
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    8. XM_036155983.1XP_036011876.1  rho-related BTB domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      Q6A003
      Conserved Domains (3) summary
      cd18530
      Location:443542
      BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
      cl38908
      Location:315440
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl38936
      Location:1058
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases