Ambp alpha-1-microglobulin/bikunin precursor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ambpprovided by RGD
Official Full Name: alpha-1-microglobulin/bikunin precursorprovided by RGD
Primary source: RGD:2102
See related: EnsemblRapid:ENSRNOG00000006889 AllianceGenome:RGD:2102
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UTI
Summary: Enables serine-type endopeptidase inhibitor activity. Involved in protein catabolic process. Located in cell surface and extracellular space. Biomarker of calcium oxalate nephrolithiasis. Human ortholog(s) of this gene implicated in acute kidney failure and adult respiratory distress syndrome. Orthologous to human AMBP (alpha-1-microglobulin/bikunin precursor). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward (RPKM 18007.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (81583621..81593938, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (76568094..76578416, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (78975690..78986021, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Ambp (e-PCR), detects polymorphism
- UniSTS:525475

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgA binding	IEA Inferred from Electronic Annotation more info
enables IgA binding	ISO Inferred from Sequence Orthology more info
enables IgA binding	ISS Inferred from Sequence or Structural Similarity more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables chondroitin sulfate binding	ISO Inferred from Sequence Orthology more info
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables collagen fibril binding	ISO Inferred from Sequence Orthology more info
enables collagen fibril binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytochrome c metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cytochrome c metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hemoglobin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in matrix side of mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein AMBP

Names: Alpha-1 microglobulin/bikunin; alpha 1 microglobulin/bikunin; ulinastatin; urinary trypsin inhibitor

NP_037033.1

EC 1.6.2.-

XP_008761981.1

EC 1.6.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429333.1 → NP_001416262.1 protein AMBP isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8L2Q3T3
NM_012901.3 → NP_037033.1 protein AMBP isoform 2 precursor

See identical proteins and their annotated locations for NP_037033.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P19603, Q63336, Q64240

UniProtKB/TrEMBL

A0A8I5ZUK6, A6J7X0

Related

ENSRNOP00000009248.4, ENSRNOT00000009248.6

Conserved Domains (2) summary

pfam00014
Location:230 → 281

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00061
Location:41 → 185

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

81583621..81593938 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008763759.4 → XP_008761981.1 protein AMBP isoform X1

Conserved Domains (2) summary

pfam00014
Location:230 → 281

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00061
Location:41 → 185

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family