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    FBXL19-AS1 FBXL19 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 283932, updated on 17-Jun-2024

    Summary

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    Official Symbol
    FBXL19-AS1provided by HGNC
    Official Full Name
    FBXL19 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:27557
    See related
    Ensembl:ENSG00000260852 AllianceGenome:HGNC:27557
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00095
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    Genomic context

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    See FBXL19-AS1 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30919319..30923269, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31306781..31310731, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30930640..30934590, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30907105-30907608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30915408-30915908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30915909-30916409 Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2, pseudogene Neighboring gene H3K27ac hESC enhancers GRCh37_chr16:30932963-30933931 and GRCh37_chr16:30933932-30934899 Neighboring gene F-box and leucine rich repeat protein 19 Neighboring gene Sharpr-MPRA regulatory region 7559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7401 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30953885-30954827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30960708-30961226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30961745-30962262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30964322-30964887 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30968383-30969146 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7406 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30974870-30975017 Neighboring gene SET domain containing 1A, histone lysine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of associations of FBXL19-AS1 with occurrence, development and prognosis of acute pancreatitis. Ma Q, et al. Eur Rev Med Pharmacol Sci, 2020 Dec. PMID 33378025
    2. Long non-coding RNA FBXL19-AS1 serves as a competing endogenous RNA to regulate ZEB1 expression by sponging miR-431 in gastric cancer. Wang XL, et al. J Biol Regul Homeost Agents, 2020 Sep-Oct. PMID 33168132
    3. LncRNA FBXL19-AS1 promotes the development of gastric cancer by regulating miR-876-5p/ HMGB3 axis. Ji RX, et al. J Biol Regul Homeost Agents, 2020 Jul-Aug,. PMID 32883406
    4. FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer. Dong G, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Nov 18. PMID 31696201
    5. LncRNA FBXL19-AS1 promotes proliferation and metastasis via regulating epithelial-mesenchymal transition in non-small cell lung cancer. Yu DJ, et al. Eur Rev Med Pharmacol Sci, 2019 Jun. PMID 31210311

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis.
      Title: Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis.
    2. IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.
      Title: IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.
    3. Analysis of associations of FBXL19-AS1 with occurrence, development and prognosis of acute pancreatitis.
      Title: Analysis of associations of FBXL19-AS1 with occurrence, development and prognosis of acute pancreatitis.
    4. Long noncoding RNA FBXL19-AS1 induces tumor growth and metastasis by sponging miR-203a-3p in lung adenocarcinoma.
      Title: Long noncoding RNA FBXL19-AS1 induces tumor growth and metastasis by sponging miR-203a-3p in lung adenocarcinoma.
    5. LncRNA FBXL19-AS1 promotes the development of gastric cancer by regulating miR-876-5p/ HMGB3 axis.
      Title: LncRNA FBXL19-AS1 promotes the development of gastric cancer by regulating miR-876-5p/ HMGB3 axis.
    6. Long non-coding RNA FBXL19-AS1 serves as a competing endogenous RNA to regulate ZEB1 expression by sponging miR-431 in gastric cancer.
      Title: Long non-coding RNA FBXL19-AS1 serves as a competing endogenous RNA to regulate ZEB1 expression by sponging miR-431 in gastric cancer.
    7. LncRNA FBXL19-AS1 promotes proliferation and metastasis via regulating epithelial-mesenchymal transition in non-small cell lung cancer.
      Title: LncRNA FBXL19-AS1 promotes proliferation and metastasis via regulating epithelial-mesenchymal transition in non-small cell lung cancer.
    8. This study revealed the regulatory mechanism of FBXL19-AS1 in breast cancer and suggested a comprehensive and feasible FBXL19-AS1-mediated therapeutic approach for treating breast cancer.
      Title: FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer.
    9. FBXL19-AS1 expression and role in cell migration, invasion, and epithelial-mesenchymal transition in breast cancer.LIN28A-stabilized FBXL19-AS1.
      Title: LIN28A-stabilized FBXL19-AS1 promotes breast cancer migration, invasion and EMT by regulating WDR66.
    10. these results indicated that FBXL19-AS1 was involved in progression and angiogenesis in lung cancer by targeting miR-431-5p/RAF1 axis, which provided a new insight into the therapeutic strategies of lung cancer.
      Title: FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • FBXL19 antisense RNA 1 (head to head)
    • FBXL19 antisense RNA 1 (non-protein coding)

    Clone Names

    • MGC125469, MGC125470, MGC125472

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024348.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC135048
      Related
      ENST00000563777.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30919319..30923269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      31306781..31310731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175901.3: Suppressed sequence

      Description
      NM_175901.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q494R0.1 GenPept UniProtKB/Swiss-Prot:Q494R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials