SPA17 sperm autoantigenic protein 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPA17provided by HGNC
Official Full Name: sperm autoantigenic protein 17provided by HGNC
Primary source: HGNC:HGNC:11210
See related: Ensembl:ENSG00000064199 MIM:608621; AllianceGenome:HGNC:11210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT22; SP17; SP17-1
Summary: This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
Expression: Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q24.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (124673904..124697518)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (124702562..124726178)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (124543800..124567414)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters.
Title: ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters.
Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome.
Title: Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome.
data suggests that SPA17, ANXA2, and SERPINA5 may potentially serve as non-invasive protein biomarkers associated with the fertilization process of the spermatozoa in unexplained male infertility
Title: Sperm Proteome Analysis and Identification of Fertility-Associated Biomarkers in Unexplained Male Infertility.
Results find that Sp17 is highly expressed in benign, borderline, and low grade malignant serous ovarian neoplasms and can be quantified in serum. Sp17 expression may have diagnostic significance in this subset of patients.
Title: Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study.
Sp17 and ASP cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.
Title: Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts.
dendritic cells from human umbilical cord blood modulated for SP17 expression induced antigen-specific anti-tumor immunity against SP17(+) non-small cell lung cancer.
Title: Umbilical cord blood-derived dendritic cells infected by adenovirus for SP17 expression induce antigen-specific cytotoxic T cells against NSCLC cells.
SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients.
Title: Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
NY-ESO-1 and SP17 was not significantly associated with a specific histotype, but high-level GAGE expression was more frequent in squamous cell carcinoma. GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC.
Title: Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma.
Sp17 is highly expressed in hepatocellular carcinoma cells
Title: Sperm protein 17, MAGE-C1 and NY-ESO-1 in hepatocellular carcinoma: expression frequency and their correlation with clinical parameters.
SP17 was expressed in many cancer types with an overall frequency of 12%. SP17 was most frequently expressed in a different set of cancer types than MAGE-A and GAGE antigens and rarely overlapped with these proteins.
Title: Limited SP17 expression within tumors diminishes its therapeutic potential.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
involved_in epithelial cilium movement involved in extracellular fluid movement	NAS Non-traceable Author Statement more info	PubMed
involved_in single fertilization	TAS Traceable Author Statement more info	PubMed
involved_in spermatogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in sperm fibrous sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm fibrous sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sperm surface protein Sp17

Names: cancer/testis antigen 22; sperm protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017425.4 → NP_059121.1 sperm surface protein Sp17

See identical proteins and their annotated locations for NP_059121.1

Status: REVIEWED

Source sequence(s)

AF334735, AP000890

Consensus CDS

CCDS8450.1

UniProtKB/Swiss-Prot

B2R4F2, Q15506, Q9BXF7

UniProtKB/TrEMBL

A0A172Q397, Q05D07

Related

ENSP00000227135.2, ENST00000227135.7

Conserved Domains (2) summary

smart00015
Location:117 → 135

IQ; Calmodulin-binding motif

cd12100
Location:12 → 50

DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

124673904..124697518

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024448583.2 → XP_024304351.1 sperm surface protein Sp17 isoform X1

UniProtKB/Swiss-Prot

B2R4F2, Q15506, Q9BXF7

UniProtKB/TrEMBL

A0A172Q397, Q05D07

Conserved Domains (2) summary

smart00015
Location:117 → 135

IQ; Calmodulin-binding motif

cd12100
Location:12 → 50

DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
XM_011542870.3 → XP_011541172.1 sperm surface protein Sp17 isoform X1

See identical proteins and their annotated locations for XP_011541172.1

UniProtKB/Swiss-Prot

B2R4F2, Q15506, Q9BXF7

UniProtKB/TrEMBL

A0A172Q397, Q05D07

Related

ENSP00000432305.1, ENST00000532692.1

Conserved Domains (2) summary

smart00015
Location:117 → 135

IQ; Calmodulin-binding motif

cd12100
Location:12 → 50

DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

124702562..124726178

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054369135.1 → XP_054225110.1 sperm surface protein Sp17 isoform X1

UniProtKB/Swiss-Prot

B2R4F2, Q15506, Q9BXF7

UniProtKB/TrEMBL

A0A172Q397
XM_054369134.1 → XP_054225109.1 sperm surface protein Sp17 isoform X1

UniProtKB/Swiss-Prot

B2R4F2, Q15506, Q9BXF7

UniProtKB/TrEMBL

A0A172Q397