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    BRS3 bombesin receptor subtype 3 [ Homo sapiens (human) ]

    Gene ID: 680, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BRS3provided by HGNC
    Official Full Name
    bombesin receptor subtype 3provided by HGNC
    Primary source
    HGNC:HGNC:1113
    See related
    Ensembl:ENSG00000102239 MIM:300107; AllianceGenome:HGNC:1113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BB3; BB3R; BBR3
    Summary
    The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    See BRS3 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136487947..136493780)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134796688..134802523)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135570106..135575939)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene adhesion G protein-coupled receptor G4 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:135434931-135436130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:135468612-135469811 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21027 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene vestigial like family member 1 Neighboring gene microRNA 934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3. Moreno P, et al. Peptides, 2018 Mar. PMID 29410320, Free PMC Article
    2. Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. Gorbulev V, et al. FEBS Lett, 1994 Mar 7. PMID 8131855
    3. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. Fathi Z, et al. J Biol Chem, 1993 Mar 15. PMID 8383682
    4. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. Ryan RR, et al. J Biol Chem, 1998 May 29. PMID 9593699
    5. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. Hou X, et al. Lung Cancer, 2006 Nov. PMID 16979789

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.
      Title: Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.
    2. BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces.
      Title: Activation of bombesin receptor Subtype-3 by [D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]bombesin(6-14) increased glucose uptake and lipogenesis in human and rat adipocytes.
    3. BRS-3 and EP3 interact to potentiate PGE2 signaling. This potentiating effect is receptor specific, and it occurs only when BRS-3 is paired to EP3.
      Title: Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.
    4. These results suggest that human BRS-3, similar to GRPR/NMBR, is frequently ectopically-expressed by lung-cancer cells in which, it is functional, affecting cell signaling/growth.
      Title: A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3.
    5. mammalian homologue of CCHa2-R, Bombesin receptor subtype-3 (Brs3), is an orphan receptor that is expressed in the islet beta-cells
      Title: The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.
    6. High BRS3 expression is associated with liver metastases of pancreas neuroendocrine tumors.
      Title: Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.
    7. The role of the human BRS-3 receptor in glucose homeostasis.
      Title: Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.
    8. Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination.
      Title: RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo.
    9. BRS-3 plays an important role in glucose metabolism.
      Title: Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
    10. BRS-3 agonist-dependent signaling mediates CREB phosphorylation and transactivation through protein kinase (PK)A, (PK)C, and mitogen-activated protein/extracellular regulated kinase kinase (MEK)-1 pathways.
      Title: A selective human bombesin receptor subtype-3 peptide agonist mediates CREB phosphorylation and transactivation.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bombesin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adult feeding behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in bombesin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of blood pressure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bombesin receptor subtype-3
    Names
    BRS-3
    G-protein coupled receptor
    bombesin like receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001727.2 → NP_001718.1  bombesin receptor subtype-3

      See identical proteins and their annotated locations for NP_001718.1

      Status: REVIEWED

      Source sequence(s)
      L08893, Z97632
      Consensus CDS
      CCDS14656.1
      UniProtKB/Swiss-Prot
      P32247
      Related
      ENSP00000359682.3, ENST00000370648.4
      Conserved Domains (1) summary
      cd15123
      Location:48 → 341
      7tmA_BRS-3; bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      136487947..136493780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134796688..134802523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32247.1 GenPept UniProtKB/Swiss-Prot:P32247

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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