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    BTG3 BTG anti-proliferation factor 3 [ Homo sapiens (human) ]

    Gene ID: 10950, updated on 14-Nov-2024

    Summary

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    Official Symbol
    BTG3provided by HGNC
    Official Full Name
    BTG anti-proliferation factor 3provided by HGNC
    Primary source
    HGNC:HGNC:1132
    See related
    Ensembl:ENSG00000154640 MIM:605674; AllianceGenome:HGNC:1132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANA; TOB5; TOFA; APRO4; TOB55; ANA/BTG3
    Summary
    The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
    Expression
    Ubiquitous expression in testis (RPKM 24.4), placenta (RPKM 23.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BTG3 in Genome Data Viewer
    Location:
    21q21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (17593653..17612901, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (15948673..15970578, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (18965971..18985219, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13222 Neighboring gene RNA, 7SL, cytoplasmic 163, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:18900282-18901218 Neighboring gene basic transcription factor 3 like 4 pseudogene 1 Neighboring gene CXADR Ig-like cell adhesion molecule Neighboring gene BTG3 antisense RNA 1 Neighboring gene uncharacterized LOC124904999 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:19038958-19040157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:19060700-19061602 Neighboring gene uncharacterized LOC124900465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18294 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18299 Neighboring gene chromosome 21 open reading frame 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of BTG3 promotes cell proliferation, migration and invasion and predicts survival in gastric cancer. Ren XL, et al. J Cancer Res Clin Oncol, 2015 Mar. PMID 25238703
    2. BTG3 upregulation induces cell apoptosis and suppresses invasion in esophageal adenocarcinoma. Du Y, et al. Mol Cell Biochem, 2015 Jun. PMID 25701359
    3. The roles of BTG3 expression in gastric cancer: a potential marker for carcinogenesis and a target molecule for gene therapy. Gou WF, et al. Oncotarget, 2015 Aug 14. PMID 25904053, Free PMC Article
    4. Downregulation of BTG3 in non-small cell lung cancer. Chen X, et al. Biochem Biophys Res Commun, 2013 Jul 19. PMID 23810394
    5. Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma. Deng B, et al. Tumour Biol, 2013 Oct. PMID 23657964, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis.
      Title: A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis.
    2. Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3.
      Title: Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3.
    3. Correlation between BTG3, CASP9 and LRP4 single-nucleotide polymorphisms and susceptibility to papillary thyroid carcinoma.
      Title: Correlation between BTG3, CASP9 and LRP4 single-nucleotide polymorphisms and susceptibility to papillary thyroid carcinoma.
    4. Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis.
      Title: Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis.
    5. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
      Title: Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
    6. Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer.
      Title: Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer.
    7. miR-519c-3p functions as a tumor promotor in regulating the growth and metastasis of hepatocellular carcinoma by targeting BTG3.
      Title: MicroRNA-519c-3p promotes tumor growth and metastasis of hepatocellular carcinoma by targeting BTG3.
    8. HOTAIRM1 might act as a tumor-suppressor in 5-fluorouracil resistant colorectal cancer cells in vitro and in vivo through downregulating miR-17-5p/BTG3 pathway and inhibiting multi-drug resistance.
      Title: The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p/ B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells.
    9. Inhibition of miR-93-5p may have blocked HPV-positive cervical cancer development by targeting of BTG3.
      Title: Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3.
    10. BTG3 overexpression inhibited cell growth, induced cell cycle arrest and suppressed the metastasis of SW480 cells via the Wnt/beta-catenin signaling pathway. BTG3 may be considered as a therapeutic target in CRC treatment.
      Title: B-cell translocation gene 3 overexpression inhibits proliferation and invasion of colorectal cancer SW480 cells via Wnt/β-catenin signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8928

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein BTG3
    Names
    B-cell translocation gene 3
    BTG family member 3
    abundant in neuroepithelium area protein
    protein Tob5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130914.2 → NP_001124386.1  protein BTG3 isoform a

      See identical proteins and their annotated locations for NP_001124386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK289408, BC011957, BF110486, DA381239
      Consensus CDS
      CCDS46636.1
      UniProtKB/Swiss-Prot
      Q14201
      UniProtKB/TrEMBL
      Q6IAU3
      Related
      ENSP00000344609.6, ENST00000339775.10
      Conserved Domains (1) summary
      cl15439
      Location:1 → 104
      BTG; BTG family

    2. NM_006806.5 → NP_006797.3  protein BTG3 isoform b

      See identical proteins and their annotated locations for NP_006797.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK289408, BF110486, DA381239, DR155504
      Consensus CDS
      CCDS13569.1
      UniProtKB/Swiss-Prot
      D3DSC4, Q14201, Q53XV1, Q96ET7
      UniProtKB/TrEMBL
      Q6IAU3
      Related
      ENSP00000284879.8, ENST00000348354.7
      Conserved Domains (1) summary
      smart00099
      Location:1 → 108
      btg1; tob/btg1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      17593653..17612901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440673.1 → XP_047296629.1  protein BTG3 isoform X4

    2. XM_011529441.2 → XP_011527743.1  protein BTG3 isoform X2

      Conserved Domains (1) summary
      cl15439
      Location:11 → 114
      BTG; BTG family

    3. XM_047440672.1 → XP_047296628.1  protein BTG3 isoform X3

    4. XM_047440670.1 → XP_047296626.1  protein BTG3 isoform X1

    5. XM_047440671.1 → XP_047296627.1  protein BTG3 isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187627.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      448..9207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      15948673..15970578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324322.1 → XP_054180297.1  protein BTG3 isoform X3

    2. XM_054324324.1 → XP_054180299.1  protein BTG3 isoform X4

    3. XM_054324321.1 → XP_054180296.1  protein BTG3 isoform X2

    4. XM_054324323.1 → XP_054180298.1  protein BTG3 isoform X3

    5. XM_054324320.1 → XP_054180295.1  protein BTG3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14201.3 GenPept UniProtKB/Swiss-Prot:Q14201

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