TGIF2 TGFB induced factor homeobox 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TGIF2provided by HGNC
Official Full Name: TGFB induced factor homeobox 2provided by HGNC
Primary source: HGNC:HGNC:15764
See related: Ensembl:ENSG00000118707 MIM:607294; AllianceGenome:HGNC:15764
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Expression: Ubiquitous expression in endometrium (RPKM 10.3), lymph node (RPKM 7.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (36573464..36593950)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (38297339..38317802)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (35201867..35222353)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of TGIF2 represents a therapeutic target that drives EMT and metastasis of lung adenocarcinoma.
Title: Phosphorylation of TGIF2 represents a therapeutic target that drives EMT and metastasis of lung adenocarcinoma.
Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p.
Title: Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p.
Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
Title: Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2.
Title: Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2.
miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2.
Title: miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2.
TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.
Title: TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.
our study identified three mRNAs (TBX21, TGIF2, and CYCS) that were significantly altered between high- and low-risk patients with breast cancer. The three-mRNA model was independent and predicted the prognosis of patients robustly. Furthermore, this model could predict survival probability precisely in patients with or without metastasis.
Title: Three inflammation-related genes could predict risk in prognosis and metastasis of patients with breast cancer.
Overexpression of TGIF1 lowers levels of cholesterol, triglycerides, and apoB. Overexpression of TGIF2 has more limited effects on lipid metabolism.
Title: Effects on hepatic lipid metabolism in human hepatoma cells following overexpression of TGFβ induced factor homeobox 1 or 2.
miRNA-34a could induce osteoarthritis synovial cell apoptosis via regulation of TGIF2 in vitro
Title: The function of microRNA-34a in osteoarthritis.
Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
Title: Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A008R12 (e-PCR)
- UniSTS:4908

RH91464 (e-PCR)
- UniSTS:84785

D20S561E (e-PCR)
- UniSTS:64316

Z94335 (e-PCR)
- UniSTS:75383

G07338 (e-PCR)
- UniSTS:83129

RH77695 (e-PCR)
- UniSTS:16603

TGIF2_2062 (e-PCR)
- UniSTS:281054

G18067 (e-PCR)
- UniSTS:76019

Readthrough TGIF2-RAB5IF

Readthrough gene: TGIF2-RAB5IF, Included gene: RAB5IF

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amacrine cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nodal signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amacrine cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of gastrulation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: homeobox protein TGIF2

Names: 5'-TG-3' interacting factor 2; TGF(beta)-induced transcription factor 2; TGFB-induced factor 2 (TALE family homeobox); transcription growth factor-beta-induced factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199513.2 → NP_001186442.1 homeobox protein TGIF2

See identical proteins and their annotated locations for NP_001186442.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.

Source sequence(s)

AL050318

Consensus CDS

CCDS13278.1

UniProtKB/Swiss-Prot

B2R9U3, E1P5T9, H0YNI0, Q9GZN2

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
NM_001199514.2 → NP_001186443.1 homeobox protein TGIF2

See identical proteins and their annotated locations for NP_001186443.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.

Source sequence(s)

AL050318

Consensus CDS

CCDS13278.1

UniProtKB/Swiss-Prot

B2R9U3, E1P5T9, H0YNI0, Q9GZN2

Related

ENSP00000362981.2, ENST00000373874.6

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
NM_001199515.2 → NP_001186444.1 homeobox protein TGIF2

See identical proteins and their annotated locations for NP_001186444.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.

Source sequence(s)

AL050318

Consensus CDS

CCDS13278.1

UniProtKB/Swiss-Prot

B2R9U3, E1P5T9, H0YNI0, Q9GZN2

Related

ENSP00000481787.1, ENST00000611732.4

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
NM_021809.7 → NP_068581.1 homeobox protein TGIF2

See identical proteins and their annotated locations for NP_068581.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.

Source sequence(s)

AL050318

Consensus CDS

CCDS13278.1

UniProtKB/Swiss-Prot

B2R9U3, E1P5T9, H0YNI0, Q9GZN2

Related

ENSP00000362979.3, ENST00000373872.9

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain