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    BCAR4 breast cancer anti-estrogen resistance 4 [ Homo sapiens (human) ]

    Gene ID: 400500, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BCAR4provided by HGNC
    Official Full Name
    breast cancer anti-estrogen resistance 4provided by HGNC
    Primary source
    HGNC:HGNC:22170
    See related
    Ensembl:ENSG00000262117 MIM:613746; AllianceGenome:HGNC:22170
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
    Expression
    Restricted expression toward placenta (RPKM 8.2) See more
    Orthologs
    all
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    Genomic context

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    See BCAR4 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11819830..11828832, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11855867..11864886, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11913687..11922689, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11836693-11837215 Neighboring gene TXNDC11 antisense RNA 1 Neighboring gene zinc finger CCCH-type containing 7A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11946068-11946601 Neighboring gene G1 to S phase transition 1 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA BCAR4 promotes proliferation, invasion and metastasis of non-small cell lung cancer cells by affecting epithelial-mesenchymal transition. Li N, et al. Eur Rev Med Pharmacol Sci, 2017 May. PMID 28537678
    2. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. Meijer D, et al. Mol Cancer Res, 2006 Jun. PMID 16778085
    3. Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer. Godinho MF, et al. Br J Cancer, 2010 Oct 12. PMID 20859285, Free PMC Article
    4. Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells. Godinho M, et al. J Cell Physiol, 2011 Jul. PMID 21506106
    5. Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines. van Agthoven T, et al. Int J Cancer, 2012 Nov 1. PMID 22328489

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression.
      Title: Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression.
    2. The role of long non-coding RNA BCAR4 in human cancers.
      Title: The role of long non-coding RNA BCAR4 in human cancers.
    3. Variant in BCAR4 gene correlated with the breast cancer susceptibility and mRNA expression of lncRNA BCAR4 in Chinese Han population.
      Title: Variant in BCAR4 gene correlated with the breast cancer susceptibility and mRNA expression of lncRNA BCAR4 in Chinese Han population.
    4. Long non-coding RNA BCAR4 aggravated proliferation and migration in esophageal squamous cell carcinoma by negatively regulating p53/p21 signaling pathway.
      Title: Long non-coding RNA BCAR4 aggravated proliferation and migration in esophageal squamous cell carcinoma by negatively regulating p53/p21 signaling pathway.
    5. Silence of lncRNA BCAR4 alleviates the deterioration of osteoporosis.
      Title: Silence of lncRNA BCAR4 alleviates the deterioration of osteoporosis.
    6. A fusion of CD63-BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis.
      Title: A fusion of CD63-BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis.
    7. Long non-coding RNA BCAR4 accelerates cell proliferation and suppresses cell apoptosis in gastric cancer via regulating MAPK/ERK signaling.
      Title: Long non-coding RNA BCAR4 accelerates cell proliferation and suppresses cell apoptosis in gastric cancer via regulating MAPK/ERK signaling.
    8. LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR1261.
      Title: LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR‑1261.
    9. lncRNA BCAR4 sponges miR3703p to promote bladder cancer progression via Wnt signaling.
      Title: lncRNA BCAR4 sponges miR‑370‑3p to promote bladder cancer progression via Wnt signaling.
    10. high BCAR4 expression was associated with clinical stage
      Title: Long noncoding RNA Breast cancer antiestrogen resistance 4 is associated with cancer progression and its significant prognostic value.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Other Names

    • breast cancer anti-estrogen resistance 4 (non-protein coding)
    • breast cancer antiestrogen resistance 4 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024049.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC010654
      Related
      ENST00000573319.1

    2. NR_024050.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks two alternate exons compared to variant 1.
      Source sequence(s)
      AC010654, BX107175
      Related
      ENST00000571259.6

    3. NR_131216.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks two alternate exons compared to variant 1.
      Source sequence(s)
      BG573316, BX107175, H03167
      Related
      ENST00000725315.1

    4. NR_131217.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks two alternate exons compared to variant 1.
      Source sequence(s)
      BG573316, BX107175
      Related
      ENST00000573037.2

    5. NR_131222.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site and lacks one alternate exon compared to variant 1.
      Source sequence(s)
      BG573316, BX107175, BX336046, R78073
      Related
      ENST00000577041.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11819830..11828832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11855867..11864886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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