ADGRF1 adhesion G protein-coupled receptor F1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRF1provided by HGNC
Official Full Name: adhesion G protein-coupled receptor F1provided by HGNC
Primary source: HGNC:HGNC:18990
See related: Ensembl:ENSG00000153292 MIM:617430; AllianceGenome:HGNC:18990
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PGR19; GPR110; KPG_012; hGPCR36
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including energy reserve metabolic process; fat cell differentiation; and nervous system development. Predicted to act upstream of or within memory and positive regulation of CREB transcription factor activity. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in urinary bladder (RPKM 9.0), kidney (RPKM 6.7) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p12.3; 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (46997708..47042332, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (46835188..46879812, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (46965445..47010068, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis.
Title: GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis.
A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer.
Title: A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer.
This signaling pathway leads to the expression of neurogenic and synaptogenic genes and suppresses the expression of proinflammatory genes. The GPR110-dependent cellular effects of synaptamide are recapitulated in animal models, suggesting that synaptamide-derived mechanisms may have translational implications.
Title: N-Docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid.
Our study revealed that high expression of GPR110 predicts the poor prognosis of gastric cancer patients, and GPTR110 may function as a potential biomarker for the diagnosis of gastric cancer.
Title: Clinicopathological and prognostic significance of aberrant G protein-couple receptor 110 (GPR110) expression in gastric cancer.
we found that GPR110 knockdown significantly reduced anchorage-dependent/independent cell growth as well as migration/invasion of parental and LTR cells and mammosphere formation in LTR derivatives and not in parental cells.
Title: GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer.
Study demonstrated orphan G-protein coupled receptor 110 (GPR110, ADGRF1) as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner.
Title: Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.
High GPR110 expression is associated with CRLF2-rearranged acute lymphoblastic leukemia.
Title: Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions.
ADGRF1 single-nucleotide polymorphisms role in susceptibility to non-small cell lung cancer
Title: Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer.
The results suggested the possible participation of STAT3 instead of ERK in the GPR110 signaling pathways and progression of glioma.
Title: Expression and prognostic role of orphan receptor GPR110 in glioma.
GPR56 and GPR110 are activated by exposure of a cryptic tethered agonist
Title: Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

NoName (e-PCR)
- UniSTS:490318

GDB:314949 (e-PCR)
- UniSTS:156503

D7S3207 (e-PCR)
- UniSTS:229489

SHGC-67307 (e-PCR)
- UniSTS:89991

NoName (e-PCR)
- UniSTS:486597

D13S1639 (e-PCR)
- UniSTS:473568

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor F1

Names: G protein-coupled receptor 110; G protein-coupled receptor PGR19; G-protein coupled receptor KPG_012; probable G-protein coupled receptor 110; seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025048.4 → NP_079324.2 adhesion G-protein coupled receptor F1 isoform 2 precursor

See identical proteins and their annotated locations for NP_079324.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3'-terminal exon, compared to variant 1, resulting in the shorter isoform (2) with a unique C-terminus, compared to isoform 1.

Source sequence(s)

AB045123, AK026337, AK095348, BC104214

Consensus CDS

CCDS4920.1

UniProtKB/Swiss-Prot

Q5T601

UniProtKB/TrEMBL

Q3SXM8

Related

ENSP00000360289.2, ENST00000371243.2

Conserved Domains (1) summary

pfam01390
Location:154 → 204

SEA; SEA domain
NM_153840.4 → NP_722582.2 adhesion G-protein coupled receptor F1 isoform 1 precursor

See identical proteins and their annotated locations for NP_722582.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB045123, AK095348, AL355518, AY140952

Consensus CDS

CCDS34471.1

UniProtKB/Swiss-Prot

Q5KU15, Q5T5Z9, Q5T600, Q5T601, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1, Q9H615

Related

ENSP00000360299.2, ENST00000371253.7

Conserved Domains (3) summary

pfam01390
Location:154 → 215

SEA; SEA domain

pfam01825
Location:532 → 572

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:582 → 834

7tm_4; Olfactory receptor