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    MAP7D3 MAP7 domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 79649, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MAP7D3provided by HGNC
    Official Full Name
    MAP7 domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:25742
    See related
    Ensembl:ENSG00000129680 MIM:300930; AllianceGenome:HGNC:25742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDP3
    Summary
    The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]
    Expression
    Broad expression in testis (RPKM 6.8), fat (RPKM 4.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAP7D3 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136213220..136256482, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134521607..134564861, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135295379..135338641, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:135225551-135226750 Neighboring gene four and a half LIM domains 1 Neighboring gene Sharpr-MPRA regulatory region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21026 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene adhesion G protein-coupled receptor G4 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:135434931-135436130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:135468612-135469811

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis. Tala, et al. Theranostics, 2014. PMID 25161703, Free PMC Article
    2. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability. Sun X, et al. Cell Cycle, 2011 Nov 15. PMID 22142902
    3. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    4. C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. Yadav S, et al. PLoS One, 2014. PMID 24927501, Free PMC Article
    5. MAP7 family proteins regulate kinesin-1 recruitment and activation. Hooikaas PJ, et al. J Cell Biol, 2019 Apr 1. PMID 30770434, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP7 proteins are microtubule-tethered kinesin-1 activators, with which the motor transiently interacts as it moves along microtubules.
      Title: MAP7 family proteins regulate kinesin-1 recruitment and activation.
    2. Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle.
      Title: DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics.
    3. the amino-terminal region mediated the interaction of Mdp3 with histone deacetylase 6 (HDAC6), in addition to its association with tubulin and microtubules.
      Title: Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.
    4. Results have identified a new microtubule binding region in MAP7D3, formed by the conserved MAP7 domain and the C-terminal tail, which can bind to microtubules and promote their assembly and stability.
      Title: C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin.
    5. A critical role for Mdp3 in the growth and metastasis of breast cancer.
      Title: Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis.
    6. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.
      Title: Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12401, FLJ12649

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP7 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016801.1 RefSeqGene

      Range
      10083..44669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173516.1 → NP_001166987.1  MAP7 domain-containing protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK301478, AL078638, AW139720, BC040518
      Consensus CDS
      CCDS55509.1
      UniProtKB/TrEMBL
      A0A0A0MRP0
      Related
      ENSP00000359697.5, ENST00000370663.9
      Conserved Domains (2) summary
      pfam05672
      Location:565 → 713
      MAP7; MAP7 (E-MAP-115) family
      pfam09805
      Location:667 → 736
      Nop25; Nucleolar protein 12 (25kDa)

    2. NM_001173517.2 → NP_001166988.1  MAP7 domain-containing protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the CDS and has an alternate 3' UTR exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AL832120, AW206053, BC064350, DB454674
      Consensus CDS
      CCDS55508.1
      UniProtKB/TrEMBL
      A0A0A0MRP0
      Related
      ENSP00000359695.1, ENST00000370661.5
      Conserved Domains (1) summary
      pfam05672
      Location:548 → 696
      MAP7; MAP7 (E-MAP-115) family

    3. NM_024597.4 → NP_078873.2  MAP7 domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_078873.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK301478, AL078638, AL832120, AW139720, BC040518, DB454674
      Consensus CDS
      CCDS44004.1
      UniProtKB/Swiss-Prot
      A2A2J0, A6NCZ7, A6NHR4, B4DWD2, H7BY77, Q5JXI5, Q5JXI6, Q6P2S1, Q8IWC1, Q9H9M8
      UniProtKB/TrEMBL
      A0A0A0MRP0
      Related
      ENSP00000318086.9, ENST00000316077.14
      Conserved Domains (3) summary
      pfam05672
      Location:583 → 731
      MAP7; MAP7 (E-MAP-115) family
      pfam15479
      Location:386 → 469
      DUF4639; Domain of unknown function (DUF4639)
      cl28033
      Location:296 → 539
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      136213220..136256482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134521607..134564861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024765.1: Suppressed sequence

      Description
      NM_024765.1: This RefSeq was permanently suppressed because it is based on sequence which has a segment rearrange problem.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWC1.2 GenPept UniProtKB/Swiss-Prot:Q8IWC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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