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    Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 14127, updated on 28-Oct-2024

    Summary

    Official Symbol
    Fcer1gprovided by MGI
    Official Full Name
    Fc receptor, IgE, high affinity I, gamma polypeptideprovided by MGI
    Primary source
    MGI:MGI:95496
    See related
    Ensembl:ENSMUSG00000058715 AllianceGenome:MGI:95496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD23; Fce1g; Ly-50; FcR[g]; FcRgamma; FcR-gamma; FcepsilonRI
    Summary
    Enables IgE receptor activity; IgG binding activity; and identical protein binding activity. Contributes to IgE binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of interleukin-4 production; and serotonin secretion by platelet. Acts upstream of or within several processes, including immune response-regulating cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of immune effector process. Located in external side of plasma membrane. Part of Fc-epsilon receptor I complex. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Orthologous to human FCER1G (Fc epsilon receptor Ig). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in spleen adult (RPKM 104.3), mammary gland adult (RPKM 62.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fcer1g in Genome Data Viewer
    Location:
    1 H3; 1 79.23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171057141..171061918, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171229572..171234349, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group I, member 3 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene apolipoprotein A-II Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene STARR-seq mESC enhancer starr_03024 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to IgE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to IgE binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables IgE receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IgE receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgE receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables IgG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IgG binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Fc receptor mediated stimulatory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Fc receptor mediated stimulatory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Fc-epsilon receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Fc-epsilon receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Fc-gamma receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Fc-gamma receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell differentiation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within T cell differentiation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to low-density lipoprotein particle stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-2 production IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in interleukin-3-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mast cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mast cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of mast cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of mast cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of mast cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of mast cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of mast cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type I hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type III hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of platelet activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in serotonin secretion by platelet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Fc-epsilon receptor I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Fc-epsilon receptor I complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of Fc-gamma receptor III complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    high affinity immunoglobulin epsilon receptor subunit gamma
    Names
    Fc receptor gamma-chain
    fc-epsilon RI-gamma
    fceRI gamma
    igE Fc receptor subunit gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010185.4NP_034315.1  high affinity immunoglobulin epsilon receptor subunit gamma precursor

      See identical proteins and their annotated locations for NP_034315.1

      Status: VALIDATED

      Source sequence(s)
      BE634435, BY173505, CK791068
      Consensus CDS
      CCDS15483.1
      UniProtKB/Swiss-Prot
      P20491
      Related
      ENSMUSP00000078875.7, ENSMUST00000079957.12
      Conserved Domains (2) summary
      smart00077
      Location:6282
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam11628
      Location:2151
      TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171057141..171061918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)