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    CUL9 cullin 9 [ Homo sapiens (human) ]

    Gene ID: 23113, updated on 28-Oct-2024

    Summary

    Official Symbol
    CUL9provided by HGNC
    Official Full Name
    cullin 9provided by HGNC
    Primary source
    HGNC:HGNC:15982
    See related
    Ensembl:ENSG00000112659 MIM:607489; AllianceGenome:HGNC:15982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARC; H7AP1
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 6.1), skin (RPKM 5.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CUL9 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43182196..43224587)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43010969..43053382)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43149934..43192325)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17218 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43049243-43049446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43050481-43051047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43051048-43051613 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43057365-43057958 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:43057959-43058553 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43058554-43059147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24591 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43086921-43087840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43087841-43088760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43099803-43100304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43100305-43100804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24592 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43138211-43138940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17219 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43139967-43140935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43145601-43146102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43146103-43146602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17221 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:43154118-43155317 Neighboring gene serum response factor Neighboring gene MPRA-validated peak5812 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43190560-43191097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43197001-43197500 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43239819-43240068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245015-43245670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245671-43246325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43254414-43255266

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686G1042, DKFZp686P2024

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cullin-9
    Names
    CUL-9
    UbcH7-associated protein 1
    p53-associated parkin-like cytoplasmic protein
    parkin-like cytoplasmic p53 binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015089.4NP_055904.1  cullin-9

      See identical proteins and their annotated locations for NP_055904.1

      Status: VALIDATED

      Source sequence(s)
      AJ318215, AL133375, BC002879, KF458162
      Consensus CDS
      CCDS4890.1
      UniProtKB/Swiss-Prot
      O75188, Q5TCY3, Q68CP2, Q68D92, Q8IWT3, Q8N3W9, Q9BU56
      UniProtKB/TrEMBL
      E9PEZ1
      Related
      ENSP00000252050.4, ENST00000252050.9
      Conserved Domains (8) summary
      smart00182
      Location:15931764
      CULLIN; Cullin
      smart00647
      Location:21412203
      IBR; In Between Ring fingers
      pfam01485
      Location:22342272
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:20682117
      zf-RING_2; Ring finger domain
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:18641944
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43182196..43224587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010589.2XP_016866078.1  cullin-9 isoform X1

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (8) summary
      smart00182
      Location:16421813
      CULLIN; Cullin
      smart00647
      Location:21902252
      IBR; In Between Ring fingers
      pfam01485
      Location:22832321
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:21172166
      zf-RING_2; Ring finger domain
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:19131993
      Cullin_Nedd8; Cullin protein neddylation domain
    2. XM_011514423.3XP_011512725.1  cullin-9 isoform X1

      See identical proteins and their annotated locations for XP_011512725.1

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (8) summary
      smart00182
      Location:16421813
      CULLIN; Cullin
      smart00647
      Location:21902252
      IBR; In Between Ring fingers
      pfam01485
      Location:22832321
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:21172166
      zf-RING_2; Ring finger domain
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:19131993
      Cullin_Nedd8; Cullin protein neddylation domain
    3. XM_047418475.1XP_047274431.1  cullin-9 isoform X3

      UniProtKB/Swiss-Prot
      O75188, Q5TCY3, Q68CP2, Q68D92, Q8IWT3, Q8N3W9, Q9BU56
    4. XM_047418478.1XP_047274434.1  cullin-9 isoform X6

    5. XM_011514422.2XP_011512724.1  cullin-9 isoform X1

      See identical proteins and their annotated locations for XP_011512724.1

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (8) summary
      smart00182
      Location:16421813
      CULLIN; Cullin
      smart00647
      Location:21902252
      IBR; In Between Ring fingers
      pfam01485
      Location:22832321
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:21172166
      zf-RING_2; Ring finger domain
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:19131993
      Cullin_Nedd8; Cullin protein neddylation domain
    6. XM_011514424.2XP_011512726.1  cullin-9 isoform X2

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (8) summary
      smart00182
      Location:16151786
      CULLIN; Cullin
      smart00647
      Location:21632225
      IBR; In Between Ring fingers
      pfam01485
      Location:22562294
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:20902139
      zf-RING_2; Ring finger domain
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11401270
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:18861966
      Cullin_Nedd8; Cullin protein neddylation domain
    7. XM_047418476.1XP_047274432.1  cullin-9 isoform X4

    8. XM_011514425.2XP_011512727.1  cullin-9 isoform X5

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (8) summary
      smart00182
      Location:15321703
      CULLIN; Cullin
      smart00647
      Location:20802142
      IBR; In Between Ring fingers
      pfam01485
      Location:21732211
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366419
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:20072056
      zf-RING_2; Ring finger domain
      pfam16195
      Location:483528
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:10571187
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:18031883
      Cullin_Nedd8; Cullin protein neddylation domain
    9. XM_047418479.1XP_047274435.1  cullin-9 isoform X7

    10. XM_047418477.1XP_047274433.1  cullin-9 isoform X6

    11. XM_047418480.1XP_047274436.1  cullin-9 isoform X9

    12. XM_011514426.2XP_011512728.1  cullin-9 isoform X8

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (8) summary
      smart00182
      Location:16421813
      CULLIN; Cullin
      smart00647
      Location:21902252
      IBR; In Between Ring fingers
      pfam01485
      Location:22832321
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam13639
      Location:21172166
      zf-RING_2; Ring finger domain
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:19131993
      Cullin_Nedd8; Cullin protein neddylation domain
    13. XM_047418481.1XP_047274437.1  cullin-9 isoform X11

    14. XM_011514428.2XP_011512730.1  cullin-9 isoform X13

      Conserved Domains (4) summary
      smart00182
      Location:16421813
      CULLIN; Cullin
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    15. XM_047418482.1XP_047274438.1  cullin-9 isoform X14

    16. XM_011514430.2XP_011512732.1  cullin-9 isoform X15

      Conserved Domains (3) summary
      pfam11515
      Location:366440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      pfam16195
      Location:593638
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:11671297
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    17. XM_047418483.1XP_047274439.1  cullin-9 isoform X15

    18. XM_011514427.1XP_011512729.1  cullin-9 isoform X10

      UniProtKB/TrEMBL
      E9PEZ1
      Conserved Domains (6) summary
      smart00182
      Location:11711342
      CULLIN; Cullin
      smart00647
      Location:17191781
      IBR; In Between Ring fingers
      pfam01485
      Location:18121850
      IBR; IBR domain, a half RING-finger domain
      pfam16195
      Location:122167
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      cl02148
      Location:696826
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl11186
      Location:14421522
      Cullin_Nedd8; Cullin protein neddylation domain
    19. XM_017010590.1XP_016866079.1  cullin-9 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      43010969..43053382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354821.1XP_054210796.1  cullin-9 isoform X1

    2. XM_054354824.1XP_054210799.1  cullin-9 isoform X3

    3. XM_054354828.1XP_054210803.1  cullin-9 isoform X6

    4. XM_054354820.1XP_054210795.1  cullin-9 isoform X1

    5. XM_054354823.1XP_054210798.1  cullin-9 isoform X2

    6. XM_054354825.1XP_054210800.1  cullin-9 isoform X4

    7. XM_054354826.1XP_054210801.1  cullin-9 isoform X5

    8. XM_054354829.1XP_054210804.1  cullin-9 isoform X7

    9. XM_054354827.1XP_054210802.1  cullin-9 isoform X6

    10. XM_054354831.1XP_054210806.1  cullin-9 isoform X9

    11. XM_054354830.1XP_054210805.1  cullin-9 isoform X8

    12. XM_054354833.1XP_054210808.1  cullin-9 isoform X11

    13. XM_054354835.1XP_054210810.1  cullin-9 isoform X13

    14. XM_054354836.1XP_054210811.1  cullin-9 isoform X14

    15. XM_054354838.1XP_054210813.1  cullin-9 isoform X15

    16. XM_054354837.1XP_054210812.1  cullin-9 isoform X15

    17. XM_054354822.1XP_054210797.1  cullin-9 isoform X1

    18. XM_054354832.1XP_054210807.1  cullin-9 isoform X10

    19. XM_054354834.1XP_054210809.1  cullin-9 isoform X12