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    SP2 Sp2 transcription factor [ Homo sapiens (human) ]

    Gene ID: 6668, updated on 28-Oct-2024

    Summary

    Official Symbol
    SP2provided by HGNC
    Official Full Name
    Sp2 transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:11207
    See related
    Ensembl:ENSG00000167182 MIM:601801; AllianceGenome:HGNC:11207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SP2 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47896236..47931731)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48758002..48793527)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45973602..46006323)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45924483-45925091 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:45931158-45931349 Neighboring gene Sp6 transcription factor Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45944035-45945234 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45963041-45963574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8643 Neighboring gene Sharpr-MPRA regulatory region 4370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8644 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45977450-45977954 Neighboring gene SP2 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45978459-45978962 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45979467-45979970 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:45981458-45981651 Neighboring gene SP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46004735-46005236 Neighboring gene Sharpr-MPRA regulatory region 5948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12320 Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46033917-46034862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46034863-46035808 Neighboring gene proline rich 15 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates Sp2 transcription factor in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003110.6NP_003101.3  transcription factor Sp2

      See identical proteins and their annotated locations for NP_003101.3

      Status: REVIEWED

      Source sequence(s)
      BC016680, BC033814, DB451570, M97190
      Consensus CDS
      CCDS11521.2
      UniProtKB/Swiss-Prot
      A6NK74, Q02086
      Related
      ENSP00000365931.4, ENST00000376741.5
      Conserved Domains (4) summary
      COG5048
      Location:449587
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:530549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:585607
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:571594
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      47896236..47931731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525139.3XP_011523441.2  transcription factor Sp2 isoform X6

    2. XM_047436575.1XP_047292531.1  transcription factor Sp2 isoform X7

    3. XM_047436573.1XP_047292529.1  transcription factor Sp2 isoform X6

    4. XM_047436571.1XP_047292527.1  transcription factor Sp2 isoform X6

    5. XM_047436570.1XP_047292526.1  transcription factor Sp2 isoform X6

    6. XM_047436572.1XP_047292528.1  transcription factor Sp2 isoform X6

    7. XM_017024968.2XP_016880457.1  transcription factor Sp2 isoform X6

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    8. XM_006722025.3XP_006722088.1  transcription factor Sp2 isoform X6

      See identical proteins and their annotated locations for XP_006722088.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    9. XM_006722027.3XP_006722090.1  transcription factor Sp2 isoform X6

      See identical proteins and their annotated locations for XP_006722090.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    10. XM_011525143.2XP_011523445.1  transcription factor Sp2 isoform X6

      See identical proteins and their annotated locations for XP_011523445.1

      Conserved Domains (4) summary
      COG5048
      Location:442580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:578600
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:564587
      zf-H2C2_2; Zinc-finger double domain
    11. XM_006722023.3XP_006722086.1  transcription factor Sp2 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:449587
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:530549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:585607
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:571594
      zf-H2C2_2; Zinc-finger double domain
    12. XM_047436569.1XP_047292525.1  transcription factor Sp2 isoform X5

    13. XM_047436576.1XP_047292532.1  transcription factor Sp2 isoform X8

    14. XM_047436577.1XP_047292533.1  transcription factor Sp2 isoform X10

    15. XM_011525136.3XP_011523438.1  transcription factor Sp2 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:553718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    16. XM_011525137.3XP_011523439.1  transcription factor Sp2 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:553718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    17. XM_011525138.3XP_011523440.1  transcription factor Sp2 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:553718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain
    18. XM_011525140.3XP_011523442.1  transcription factor Sp2 isoform X9

      Conserved Domains (4) summary
      COG5048
      Location:553691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:634653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:689711
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:675698
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      48758002..48793527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316988.1XP_054172963.1  transcription factor Sp2 isoform X10

    2. XM_054316981.1XP_054172956.1  transcription factor Sp2 isoform X6

    3. XM_054316978.1XP_054172953.1  transcription factor Sp2 isoform X6

    4. XM_054316977.1XP_054172952.1  transcription factor Sp2 isoform X6

    5. XM_054316980.1XP_054172955.1  transcription factor Sp2 isoform X6

    6. XM_054316982.1XP_054172957.1  transcription factor Sp2 isoform X6

    7. XM_054316976.1XP_054172951.1  transcription factor Sp2 isoform X6

    8. XM_054316979.1XP_054172954.1  transcription factor Sp2 isoform X6

    9. XM_054316983.1XP_054172958.1  transcription factor Sp2 isoform X6

    10. XM_054316974.1XP_054172949.1  transcription factor Sp2 isoform X4

    11. XM_054316975.1XP_054172950.1  transcription factor Sp2 isoform X5

    12. XM_054316986.1XP_054172961.1  transcription factor Sp2 isoform X8

    13. XM_054316985.1XP_054172960.1  transcription factor Sp2 isoform X7

    14. XM_054316984.1XP_054172959.1  transcription factor Sp2 isoform X6

    15. XM_054316971.1XP_054172946.1  transcription factor Sp2 isoform X1

    16. XM_054316972.1XP_054172947.1  transcription factor Sp2 isoform X2

    17. XM_054316973.1XP_054172948.1  transcription factor Sp2 isoform X3

    18. XM_054316987.1XP_054172962.1  transcription factor Sp2 isoform X9