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    GPR61 G protein-coupled receptor 61 [ Homo sapiens (human) ]

    Gene ID: 83873, updated on 28-Oct-2024

    Summary

    Official Symbol
    GPR61provided by HGNC
    Official Full Name
    G protein-coupled receptor 61provided by HGNC
    Primary source
    HGNC:HGNC:13300
    See related
    Ensembl:ENSG00000156097 MIM:606916; AllianceGenome:HGNC:13300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BALGR; GPCR3
    Summary
    This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 1.2), thyroid (RPKM 0.5) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR61 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109539872..109547260)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109572595..109579983)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110082494..110089882)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1155 Neighboring gene uncharacterized LOC105378893 Neighboring gene adhesion molecule with Ig like domain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1443 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110073289-110073457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082007-110082508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082509-110083008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110086313-110086851 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110089013-110089249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1445 Neighboring gene G protein subunit alpha i3 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:110106789-110107398 Neighboring gene RNA, U6 small nuclear variant sequence with SNRPE pseudogene sequence Neighboring gene microRNA 197

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arrestin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G-protein coupled receptor 61
    Names
    biogenic amine receptor-like G-protein coupled receptor
    biogenic amine receptor-like GPCR
    probable G-protein coupled receptor 61

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032758.2 RefSeqGene

      Range
      5001..12389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393907.1NP_001380836.1  G-protein coupled receptor 61

      Status: REVIEWED

      Source sequence(s)
      AL355145, AL355310
      Consensus CDS
      CCDS801.1
      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
      Related
      ENSP00000432456.1, ENST00000527748.5
      Conserved Domains (1) summary
      cd15220
      Location:44352
      7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_031936.6NP_114142.3  G-protein coupled receptor 61

      See identical proteins and their annotated locations for NP_114142.3

      Status: REVIEWED

      Source sequence(s)
      AF258342, AL355310, DA176879
      Consensus CDS
      CCDS801.1
      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
      Related
      ENSP00000385422.2, ENST00000404129.6
      Conserved Domains (1) summary
      cd15220
      Location:44352
      7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      109539872..109547260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431615.1XP_047287571.1  G-protein coupled receptor 61 isoform X1

      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
    2. XM_047431617.1XP_047287573.1  G-protein coupled receptor 61 isoform X1

      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
      Related
      ENSP00000433661.1, ENST00000469383.2
    3. XM_047431614.1XP_047287570.1  G-protein coupled receptor 61 isoform X1

      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      109572595..109579983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486172.1 RNA Sequence

    2. XR_008486171.1 RNA Sequence

    3. XR_008486173.1 RNA Sequence

    4. XR_008486174.1 RNA Sequence