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    FCGR2A Fc gamma receptor IIa [ Homo sapiens (human) ]

    Gene ID: 2212, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FCGR2Aprovided by HGNC
    Official Full Name
    Fc gamma receptor IIaprovided by HGNC
    Primary source
    HGNC:HGNC:3616
    See related
    Ensembl:ENSG00000143226 MIM:146790; AllianceGenome:HGNC:3616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; FcgammaRIIa
    Summary
    This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
    Expression
    Broad expression in appendix (RPKM 39.7), placenta (RPKM 36.5) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FCGR2A in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161505457..161524048)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160768080..160786676)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161475247..161489619)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Gly (anticodon GCC) 4-1 Neighboring gene uncharacterized LOC105371473 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161460810-161461039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1992 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9514 Neighboring gene tRNA-Asp (GTC) 10-1 Neighboring gene tRNA-Gly (anticodon GCC) 2-1 Neighboring gene heat shock protein family A (Hsp70) member 6 Neighboring gene tRNA-Leu (anticodon CAG) 1-6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of the FcgammaRIIA promoter and 5'UTR sequences in patients with systemic lupus erythematosus. Pricop L, et al. Genes Immun, 2002 Oct. PMID 12215902
    2. Is Fc gamma receptor IIA (FcÎłRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? Cherif MK, et al. Acta Trop, 2015 Feb. PMID 25447268
    3. Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. Karassa FB, et al. Arthritis Rheum, 2002 Jun. PMID 12115187
    4. A novel FcÎłRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcÎłRIIa downstream signaling. Flinsenberg TWH, et al. Clin Immunol, 2014 Nov. PMID 25242138
    5. Dynamics of the interaction of human IgG subtype immune complexes with cells expressing R and H allelic forms of a low-affinity Fc gamma receptor CD32A. Shashidharamurthy R, et al. J Immunol, 2009 Dec 15. PMID 20007585, Free PMC Article

    See all (534) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD32 captures committed haemogenic endothelial cells during human embryonic development.
      Title: CD32 captures committed haemogenic endothelial cells during human embryonic development.
    2. Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
      Title: Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
    3. Genetic variation of FcgammaRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
      Title: Genetic variation of FcÎłRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
    4. New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.
      Title: New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.
    5. Platelet FcgammaRIIa expression in patients with stable coronary artery disease.
      Title: Platelet FcÎłRIIa expression in patients with stable coronary artery disease.
    6. Relationship Between Human FCgammaRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants.
      Title: Relationship Between Human FCÎłRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants.
    7. Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
      Title: Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
    8. Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
      Title: Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
    9. Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.
      Title: Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.
    10. Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
      Title: Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
    Submit: New GeneRIF Correction See all GeneRIFs (353)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cystic fibrosis
    MedGen: C0010674 OMIM: 219700 GeneReviews: Cystic Fibrosis
    		Compare labs
    Malaria, susceptibility to
    MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
    		Compare labs
    Systemic lupus erythematosus
    MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
    EBI GWAS Catalog
    Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
    EBI GWAS Catalog
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of genetic loci associated with Helicobacter pylori serologic status.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC23887, MGC30032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibody-dependent cellular cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor II-a
    Names
    Fc fragment of IgG receptor IIa
    Fc fragment of IgG, low affinity IIa, receptor (CD32)
    Fc gamma receptor RIIa3
    Immunoglobulin G Fc receptor II
    fc-gamma-RIIa
    fcRII-a
    igG Fc receptor II-a

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012066.2 RefSeqGene

      Range
      5043..19415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1109

    mRNA and Protein(s)

    1. NM_001136219.3 → NP_001129691.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

      See identical proteins and their annotated locations for NP_001129691.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA634082, AK315225, AL590385
      Consensus CDS
      CCDS44264.1
      UniProtKB/Swiss-Prot
      P12318, Q8WUN1, Q8WW64
      UniProtKB/TrEMBL
      A0A346JF56
      Related
      ENSP00000271450.6, ENST00000271450.12
      Conserved Domains (3) summary
      cd05752
      Location:41 → 119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 → 205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129 → 205
      IG_like; Immunoglobulin like

    2. NM_001375296.1 → NP_001362225.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL590385, BC019931, BX379627
      Consensus CDS
      CCDS91088.1
      UniProtKB/TrEMBL
      A0A346JF56, A0A8V8TPS4
      Related
      ENSP00000514258.1, ENST00000699277.1
      Conserved Domains (2) summary
      cd05752
      Location:41 → 119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 → 205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    3. NM_001375297.1 → NP_001362226.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL590385
      UniProtKB/TrEMBL
      A0A346JF56
      Conserved Domains (2) summary
      cd05752
      Location:40 → 118
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122 → 204
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    4. NM_021642.5 → NP_067674.2  low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL590385, BC019931
      Consensus CDS
      CCDS30922.1
      UniProtKB/TrEMBL
      A0A346JF56
      Related
      ENSP00000356949.4, ENST00000367972.8
      Conserved Domains (3) summary
      cd05752
      Location:40 → 118
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122 → 204
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:128 → 204
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161505457..161524048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000664.2 → XP_016856153.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

      UniProtKB/TrEMBL
      A0A346JF56

    2. XM_017000665.2 → XP_016856154.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

      UniProtKB/TrEMBL
      A0A346JF56

    3. XM_017000666.2 → XP_016856155.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

      UniProtKB/TrEMBL
      A0A346JF56
      Conserved Domains (3) summary
      cd05752
      Location:41 → 119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 → 205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129 → 205
      IG_like; Immunoglobulin like

    4. XM_047449441.1 → XP_047305397.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1

    5. XM_017000663.3 → XP_016856152.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

      UniProtKB/TrEMBL
      A0A346JF56
      Conserved Domains (3) summary
      cd05752
      Location:40 → 118
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:122 → 204
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:128 → 204
      IG_like; Immunoglobulin like

    6. XM_011509290.3 → XP_011507592.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

      UniProtKB/TrEMBL
      A0A346JF56
      Conserved Domains (3) summary
      cd05752
      Location:41 → 119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 → 205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129 → 205
      IG_like; Immunoglobulin like

    7. XM_011509291.2 → XP_011507593.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X6

      Conserved Domains (3) summary
      cd05752
      Location:41 → 119
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:123 → 205
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:129 → 205
      IG_like; Immunoglobulin like

    8. XM_024454040.2 → XP_024309808.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X7

      Conserved Domains (1) summary
      cd05753
      Location:1 → 66
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160768080..160786676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335134.1 → XP_054191109.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

    2. XM_054335135.1 → XP_054191110.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

    3. XM_054335136.1 → XP_054191111.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

    4. XM_054335132.1 → XP_054191107.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1

    5. XM_054335133.1 → XP_054191108.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

    6. XM_054335137.1 → XP_054191112.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

    7. XM_054335138.1 → XP_054191113.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12318.4 GenPept UniProtKB/Swiss-Prot:P12318

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