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    OR2T1 olfactory receptor family 2 subfamily T member 1 [ Homo sapiens (human) ]

    Gene ID: 26696, updated on 28-Oct-2024

    Summary

    Official Symbol
    OR2T1provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily T member 1provided by HGNC
    Primary source
    HGNC:HGNC:8277
    See related
    Ensembl:ENSG00000175143 AllianceGenome:HGNC:8277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR1-25
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See OR2T1 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248403048..248408020)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247828076..247833646)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248566349..248571321)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 4 Neighboring gene olfactory receptor family 2 subfamily T member 6 Neighboring gene MPRA-validated peak838 silencer Neighboring gene MPRA-validated peak839 silencer Neighboring gene olfactory receptor family 2 subfamily T member 7 (gene/pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr1:248616387-248616588 Neighboring gene olfactory receptor family 2 subfamily T member 2

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 2T1
    Names
    olfactory receptor 1-25
    olfactory receptor OR1-61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051766.1 RefSeqGene

      Range
      2054..7026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030904.2NP_112166.2  olfactory receptor 2T1

      Status: VALIDATED

      Source sequence(s)
      AC138089
      Consensus CDS
      CCDS31115.2
      UniProtKB/TrEMBL
      A0A126GW40, A0A126GWK9, A0A126GWM2
      Related
      ENSP00000493164.1, ENST00000642005.1
      Conserved Domains (1) summary
      cd15421
      Location:36300
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248403048..248408020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791755.1 Reference GRCh38.p14 PATCHES

      Range
      51022..55994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187518.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      51363..62060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187646.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      51362..58226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      247828076..247833646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)