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    IL17F interleukin 17F [ Homo sapiens (human) ]

    Gene ID: 112744, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IL17Fprovided by HGNC
    Official Full Name
    interleukin 17Fprovided by HGNC
    Primary source
    HGNC:HGNC:16404
    See related
    Ensembl:ENSG00000112116 MIM:606496; AllianceGenome:HGNC:16404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ML1; ML-1; IL17A; CANDF6; IL-17F
    Summary
    The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See IL17F in Genome Data Viewer
    Location:
    6p12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (52236681..52245689, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52075437..52084442, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52101479..52109298, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene interleukin 17A Neighboring gene uncharacterized LOC102724327 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24669 Neighboring gene uncharacterized LOC124901328 Neighboring gene solute carrier family 25 member 20 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:52129168-52129587 Neighboring gene minichromosome maintenance complex component 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren's Syndrome. Gan Y, et al. J Immunol Res, 2017. PMID 28210632, Free PMC Article
    2. IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia. Wróbel T, et al. J Cancer Res Clin Oncol, 2014 Sep. PMID 24793548, Free PMC Article
    3. Role of IL-17F T7488C polymorphism in carcinogenesis: a meta-analysis. Yao F, et al. Tumour Biol, 2014 Sep. PMID 24913709
    4. Increased plasma IL-17F levels in rheumatoid arthritis patients are responsive to methotrexate, anti-TNF, and T cell costimulatory modulation. Jain M, et al. Inflammation, 2015 Feb. PMID 25240765, Free PMC Article
    5. Meta analysis of association of the IL-17F rs763780T>C gene polymorphism with cancer risk. Chen XJ, et al. Asian Pac J Cancer Prev, 2014. PMID 25338988

    See all (257) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis.
      Title: Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis.
    2. Association of interleukin-17F (rs763780) single nucleotide polymorphism with multiple sclerosis and optic neuritis.
      Title: Association of interleukin-17F (rs763780) single nucleotide polymorphism with multiple sclerosis and optic neuritis.
    3. Association of IL-17F rs763780 polymorphism and risk of psoriasis in Turkish population: a case-control study.
      Title: Association of IL-17F rs763780 polymorphism and risk of psoriasis in Turkish population: a case-control study.
    4. Dual blockade of interleukin-17A and interleukin-17F as a therapeutic strategy for liver fibrosis: Investigating the potential effect and mechanism of brodalumab.
      Title: Dual blockade of interleukin-17A and interleukin-17F as a therapeutic strategy for liver fibrosis: Investigating the potential effect and mechanism of brodalumab.
    5. Association of Interleukin-17A and Interleukin-17F Gene Polymorphisms with Atopic Dermatitis in Chinese Children.
      Title: Association of Interleukin-17A and Interleukin-17F Gene Polymorphisms with Atopic Dermatitis in Chinese Children.
    6. Association of polymorphism of IL-17A, IL-17F, and IL-6 with Toxoplasma gondii infection susceptibility in HIV/AIDS patients in Shiraz, southern Iran.
      Title: Association of polymorphism of IL-17A, IL-17F, and IL-6 with Toxoplasma gondii infection susceptibility in HIV/AIDS patients in Shiraz, southern Iran.
    7. Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19.
      Title: Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19.
    8. Association between Interleukin-17F 7488A/G and 7383A/G polymorphisms and susceptibility to juvenile idiopathic arthritis.
      Title: Association between Interleukin-17F 7488A/G and 7383A/G polymorphisms and susceptibility to juvenile idiopathic arthritis.
    9. Associations of IL-17 and IL-17 receptor polymorphisms with Behcet's disease in Denizli Province of Turkey.
      Title: Associations of IL-17 and IL-17 receptor polymorphisms with Behçet's disease in Denizli Province of Turkey.
    10. Association of IL-17F rs2397084 (E126G), rs11465553 (V155I) and rs763780 (H161R) variants with rheumatoid arthritis and their effects on the stability of protein.
      Title: Association of IL-17F rs2397084 (E126G), rs11465553 (V155I) and rs763780 (H161R) variants with rheumatoid arthritis and their effects on the stability of protein.
    Submit: New GeneRIF Correction See all GeneRIFs (240)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Candidiasis, familial, 6
    MedGen: C3151405 OMIM: 613956 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cartilage development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-17-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lymphotoxin A production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of granulocyte macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17F
    Names
    cytokine ML-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031869.1 RefSeqGene

      Range
      5001..12815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_356

    mRNA and Protein(s)

    1. NM_052872.4 → NP_443104.1  interleukin-17F precursor

      See identical proteins and their annotated locations for NP_443104.1

      Status: REVIEWED

      Source sequence(s)
      AF332389, BC070124
      Consensus CDS
      CCDS4938.1
      UniProtKB/Swiss-Prot
      Q6NSI0, Q7Z6P4, Q96PD4, Q96PI8, Q9NUE6
      UniProtKB/TrEMBL
      F1JZ09
      Related
      ENSP00000337432.4, ENST00000336123.5
      Conserved Domains (1) summary
      pfam06083
      Location:80 → 154
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      52236681..52245689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514276.1 → XP_011512578.1  interleukin-17F isoform X1

      See identical proteins and their annotated locations for XP_011512578.1

      UniProtKB/Swiss-Prot
      Q6NSI0, Q7Z6P4, Q96PD4, Q96PI8, Q9NUE6
      UniProtKB/TrEMBL
      F1JZ09
      Related
      ENSP00000514702.1, ENST00000699946.1
      Conserved Domains (1) summary
      pfam06083
      Location:80 → 154
      IL17; Interleukin-17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      52075437..52084442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354142.1 → XP_054210117.1  interleukin-17F isoform X1

      UniProtKB/Swiss-Prot
      Q6NSI0, Q7Z6P4, Q96PD4, Q96PI8, Q9NUE6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172343.1: Suppressed sequence

      Description
      NM_172343.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PD4.3 GenPept UniProtKB/Swiss-Prot:Q96PD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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