LRRC26 leucine rich repeat containing 26 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LRRC26provided by HGNC
Official Full Name: leucine rich repeat containing 26provided by HGNC
Primary source: HGNC:HGNC:31409
See related: Ensembl:ENSG00000184709 MIM:613505; AllianceGenome:HGNC:31409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAPC; bA350O14.10
Summary: Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in prostate (RPKM 24.0), colon (RPKM 13.3) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 9q34.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (137168758..137170051, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (149406438..149407731, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (140063210..140064503, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that BK channel modulation by auxiliary gamma subunits depends on intra- and/or juxta-membrane mechanisms.
Title: Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.
Regulation of the Ca(2+)- and voltage-activated large conductance Ca(2+)-activated K(+) (BK) channel by associated gamma1-subunits, was investigated.
Title: Functional regulation of BK potassium channels by γ1 auxiliary subunits.
The role of CAPC in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment.
Title: CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis.
in non-excitable LNCaP prostate cancer cells, BK channels can be activated at negative voltages without rises in [Ca(2+)](i) through their complex with an auxiliary protein, leucine-rich repeat (LRR)-containing protein 26 (LRRC26)
Title: LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium.
CAPC transcripts have differential expression in cancer cell lines, and that S-CAPC is translated into a 7.5 kDa protein using a non-AUG start codon.
Title: Non-AUG translational initiation of a short CAPC transcript generating protein isoform.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat-containing protein 26

Names: BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26; cytokeratin associated protein; cytokeratin-associated protein in cancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013653.3 → NP_001013675.1 leucine-rich repeat-containing protein 26 precursor

See identical proteins and their annotated locations for NP_001013675.1

Status: VALIDATED

Source sequence(s)

AL929554

Consensus CDS

CCDS35184.1

UniProtKB/Swiss-Prot

B9EIR7, C3RUL3, Q2I0M4, Q5VSG2

Related

ENSP00000360597.3, ENST00000371542.3

Conserved Domains (3) summary

cd00116
Location:97 → 253

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:97 → 120

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:97 → 155

LRR_8; Leucine rich repeat