DGKA diacylglycerol kinase alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: DGKAprovided by HGNC
Official Full Name: diacylglycerol kinase alphaprovided by HGNC
Primary source: HGNC:HGNC:2849
See related: Ensembl:ENSG00000065357 MIM:125855; AllianceGenome:HGNC:2849
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAGK; DAGK1; DGK-alpha
Summary: The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Expression: Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.2

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (55927316..55954023)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (55894378..55921085)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56321100..56347807)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis.
Title: Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis.
Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase alpha (DGKalpha)/NOX4 axis.
Title: Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis.
Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase alpha (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma.
Title: Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma.
Targeting diacylglycerol kinase alpha impairs lung tumorigenesis by inhibiting cyclin D3.
Title: Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.
DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer.
Title: DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer.
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
Title: Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
DGKA Mediates Resistance to PD-1 Blockade.
Title: DGKA Mediates Resistance to PD-1 Blockade.
DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Title: DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Diacylglycerol kinases regulate TRPV1 channel activity.
Title: Diacylglycerol kinases regulate TRPV1 channel activity.
Upon neutrophil stimulation, DGK-alpha activation is necessary for migration and a productive response. This paper focuses on the role of DGK-alpha in obstructive respiratory diseases, including asthma and chronic obstructive pulmonary disease, but also rare genetic diseases such as alpha-1-antitrypsin deficiency. [review]
Title: DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EST8E12 (e-PCR)
- UniSTS:263430

STS-D29052 (e-PCR)
- UniSTS:51742

RH68207 (e-PCR)
- UniSTS:31537

G06345 (e-PCR)
- UniSTS:65845

SHGC-5310 (e-PCR)
- UniSTS:28023

STS-X62535 (e-PCR)
- UniSTS:40339

D12S53E (e-PCR)
- UniSTS:150202

STS-N23118 (e-PCR)
- UniSTS:58831

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	TAS Traceable Author Statement more info
enables alkylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet activation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: diacylglycerol kinase alpha

Names: 80 kDa diacylglycerol kinase; DAG kinase alpha; diacylglycerol kinase, alpha 80kDa; diglyceride kinase alpha

NP_001336.2

EC 2.7.1.107

EC 2.7.1.93

NP_001337962.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337963.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337964.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337965.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337966.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337967.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337968.1

EC 2.7.1.107

EC 2.7.1.93

NP_001337969.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400525.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400526.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400527.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400528.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400529.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400530.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400531.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400532.1

EC 2.7.1.107

EC 2.7.1.93

NP_001400533.1

EC 2.7.1.107

EC 2.7.1.93

NP_958852.1

EC 2.7.1.107

EC 2.7.1.93

NP_958853.1

EC 2.7.1.107

EC 2.7.1.93

NP_963848.1

EC 2.7.1.107

EC 2.7.1.93

XP_011536297.1

EC 2.7.1.107

EC 2.7.1.93

XP_016874389.1

EC 2.7.1.107

EC 2.7.1.93

XP_016874390.1

EC 2.7.1.107

EC 2.7.1.93

XP_016874391.1

EC 2.7.1.107

EC 2.7.1.93

XP_016874396.1

EC 2.7.1.107

EC 2.7.1.93

XP_016874397.1

EC 2.7.1.107

EC 2.7.1.93

XP_047284390.1

EC 2.7.1.107

EC 2.7.1.93

XP_047284391.1

EC 2.7.1.107

EC 2.7.1.93

XP_047284392.1

EC 2.7.1.107

EC 2.7.1.93

XP_047284393.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227256.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227257.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227258.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227259.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227260.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227261.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227262.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227263.1

EC 2.7.1.107

EC 2.7.1.93

XP_054227264.1

EC 2.7.1.107

EC 2.7.1.93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001345.5 → NP_001336.2 diacylglycerol kinase alpha isoform a

See identical proteins and their annotated locations for NP_001336.2

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variants 1, 2, 4-6, and 15-17, encodes isoform a.

Source sequence(s)

BC023523, BC031870, BM836118, BQ943057

Consensus CDS

CCDS8896.1

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2

Related

ENSP00000328405.5, ENST00000331886.10

Conserved Domains (5) summary

smart00045
Location:520 → 701

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:378 → 499

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:114 → 183

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:206 → 254

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:4 → 110

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001351033.2 → NP_001337962.1 diacylglycerol kinase alpha isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 1-4, 6, and 15-17, encodes isoform a.

Source sequence(s)

AC025162, BC031870

Consensus CDS

CCDS8896.1

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2

Related

ENSP00000450359.1, ENST00000551156.5

Conserved Domains (5) summary

smart00045
Location:520 → 701

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:378 → 499

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:114 → 183

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:206 → 254

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:4 → 110

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001351034.2 → NP_001337963.1 diacylglycerol kinase alpha isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1-5 and 15-17, encodes isoform a.

Source sequence(s)

AC025162

Consensus CDS

CCDS8896.1

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2

Conserved Domains (5) summary

smart00045
Location:520 → 701

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:378 → 499

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:114 → 183

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:206 → 254

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:4 → 110

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001351035.1 → NP_001337964.1 diacylglycerol kinase alpha isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (7) encodes the longest isoform (b).

Source sequence(s)

AC025162

Conserved Domains (5) summary

smart00045
Location:558 → 739

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:416 → 537

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:152 → 221

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:244 → 292

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:42 → 148

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001351036.2 → NP_001337965.1 diacylglycerol kinase alpha isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variant 9, encodes isoform c.

Source sequence(s)

AC025162

UniProtKB/TrEMBL

G3V4E1

Conserved Domains (4) summary

smart00045
Location:379 → 560

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:237 → 358

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:65 → 113

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl08302
Location:1 → 42

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001351037.1 → NP_001337966.1 diacylglycerol kinase alpha isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variant 8, encodes isoform c.

Source sequence(s)

AC025162

UniProtKB/TrEMBL

G3V4E1

Conserved Domains (4) summary

smart00045
Location:379 → 560

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:237 → 358

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:65 → 113

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl08302
Location:1 → 42

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001351038.2 → NP_001337967.1 diacylglycerol kinase alpha isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform d.

Source sequence(s)

AC025162

Conserved Domains (2) summary

smart00045
Location:166 → 347

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:24 → 145

DAGKc; Diacylglycerol kinase catalytic domain (presumed)
NM_001351039.2 → NP_001337968.1 diacylglycerol kinase alpha isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform d.

Source sequence(s)

AC025162

Conserved Domains (2) summary

smart00045
Location:166 → 347

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:24 → 145

DAGKc; Diacylglycerol kinase catalytic domain (presumed)
NM_001351040.2 → NP_001337969.1 diacylglycerol kinase alpha isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform d.

Source sequence(s)

AC025162

Conserved Domains (2) summary

smart00045
Location:166 → 347

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:24 → 145

DAGKc; Diacylglycerol kinase catalytic domain (presumed)
NM_001413596.1 → NP_001400525.1 diacylglycerol kinase alpha isoform a

Status: REVIEWED

Source sequence(s)

AC025162

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
NM_001413597.1 → NP_001400526.1 diacylglycerol kinase alpha isoform a

Status: REVIEWED

Source sequence(s)

AC025162

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
NM_001413598.1 → NP_001400527.1 diacylglycerol kinase alpha isoform a

Status: REVIEWED

Source sequence(s)

AC025162

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
NM_001413599.1 → NP_001400528.1 diacylglycerol kinase alpha isoform e

Status: REVIEWED

Source sequence(s)

AC025162
NM_001413600.1 → NP_001400529.1 diacylglycerol kinase alpha isoform e

Status: REVIEWED

Source sequence(s)

AC025162
NM_001413601.1 → NP_001400530.1 diacylglycerol kinase alpha isoform e

Status: REVIEWED

Source sequence(s)

AC025162
NM_001413602.1 → NP_001400531.1 diacylglycerol kinase alpha isoform f

Status: REVIEWED

Source sequence(s)

AC025162
NM_001413603.1 → NP_001400532.1 diacylglycerol kinase alpha isoform f

Status: REVIEWED

Source sequence(s)

AC025162
NM_001413604.1 → NP_001400533.1 diacylglycerol kinase alpha isoform g

Status: REVIEWED

Source sequence(s)

AC025162
NM_201444.3 → NP_958852.1 diacylglycerol kinase alpha isoform a

See identical proteins and their annotated locations for NP_958852.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), as well as variants 2-6 and 15-17, encodes isoform a.

Source sequence(s)

AI815678, BC023523, BC031870, BM910598

Consensus CDS

CCDS8896.1

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2

Related

ENSP00000377703.1, ENST00000394147.5

Conserved Domains (5) summary

smart00045
Location:520 → 701

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:378 → 499

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:114 → 183

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:206 → 254

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:4 → 110

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_201445.2 → NP_958853.1 diacylglycerol kinase alpha isoform a

See identical proteins and their annotated locations for NP_958853.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), as well as variants 1, 3-6, and 15-17, encodes isoform a.

Source sequence(s)

BC023523, BC031870, BF448612

Consensus CDS

CCDS8896.1

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2

Conserved Domains (5) summary

smart00045
Location:520 → 701

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:378 → 499

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:114 → 183

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:206 → 254

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:4 → 110

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_201554.2 → NP_963848.1 diacylglycerol kinase alpha isoform a

See identical proteins and their annotated locations for NP_963848.1

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 1-3, 5, 6, and 15-17, encodes isoform a.

Source sequence(s)

BC023523, BC031870, BF448612

Consensus CDS

CCDS8896.1

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2

Conserved Domains (5) summary

smart00045
Location:520 → 701

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:378 → 499

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:114 → 183

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:206 → 254

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam14513
Location:4 → 110

DAG_kinase_N; Diacylglycerol kinase N-terminus

RNA

NR_147026.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC025162

Related

ENST00000402956.7
NR_147027.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC025162

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

55927316..55954023

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017018901.3 → XP_016874390.1 diacylglycerol kinase alpha isoform X2
XM_047428435.1 → XP_047284391.1 diacylglycerol kinase alpha isoform X4

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
XM_017018907.2 → XP_016874396.1 diacylglycerol kinase alpha isoform X2
XM_047428434.1 → XP_047284390.1 diacylglycerol kinase alpha isoform X4

UniProtKB/Swiss-Prot

O75481, O75482, O75483, O95217, P23743, Q3ZE25, Q8IZ56, Q8N5Q2
XM_017018902.2 → XP_016874391.1 diacylglycerol kinase alpha isoform X2
XM_017018900.1 → XP_016874389.1 diacylglycerol kinase alpha isoform X1
XM_017018908.1 → XP_016874397.1 diacylglycerol kinase alpha isoform X3
XM_047428436.1 → XP_047284392.1 diacylglycerol kinase alpha isoform X5
XM_047428437.1 → XP_047284393.1 diacylglycerol kinase alpha isoform X6
XM_011537995.3 → XP_011536297.1 diacylglycerol kinase alpha isoform X7

See identical proteins and their annotated locations for XP_011536297.1

Related

ENST00000549079.6

Conserved Domains (4) summary

smart00045
Location:408 → 589

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:266 → 387

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:94 → 142

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl08302
Location:30 → 71

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...