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    DUSP14 dual specificity phosphatase 14 [ Homo sapiens (human) ]

    Gene ID: 11072, updated on 28-Oct-2024

    Summary

    Official Symbol
    DUSP14provided by HGNC
    Official Full Name
    dual specificity phosphatase 14provided by HGNC
    Primary source
    HGNC:HGNC:17007
    See related
    Ensembl:ENSG00000276023 MIM:606618; AllianceGenome:HGNC:17007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKP6; MKP-L
    Summary
    Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
    Expression
    Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DUSP14 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37488566..37513498)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38472550..38500180)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35849997..35873600)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene synergin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210 Neighboring gene microRNA 378j Neighboring gene DExD-box helicase 52

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
    EBI GWAS Catalog
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 14
    Names
    MAP kinase phosphatase 6
    MKP-1-like protein tyrosine phosphatase
    MKP-6
    mitogen-activated protein kinase phosphatase 6
    NP_008957.1
    XP_005257034.1
    XP_011522536.1
    XP_047291173.1
    XP_054170826.1
    XP_054170827.1
    XP_054170828.1
    XP_054170829.1
    XP_054185204.1
    XP_054185205.1
    XP_054185206.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007026.4NP_008957.1  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_008957.1

      Status: VALIDATED

      Source sequence(s)
      AC243585, AC243654
      Consensus CDS
      CCDS11320.1
      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
      Related
      ENSP00000478595.1, ENST00000617516.5
      Conserved Domains (1) summary
      cd14572
      Location:20169
      DUSP14; dual specificity protein phosphatase 14

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      37488566..37513498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524234.2XP_011522536.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_011522536.1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
      Conserved Domains (1) summary
      cd14572
      Location:20169
      DUSP14; dual specificity protein phosphatase 14
    2. XM_047435217.1XP_047291173.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    3. XM_005256977.4XP_005257034.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_005257034.1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
      Related
      ENSP00000484091.1, ENST00000613659.1
      Conserved Domains (1) summary
      cd14572
      Location:20169
      DUSP14; dual specificity protein phosphatase 14

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1725025..1752665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329231.1XP_054185206.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    2. XM_054329230.1XP_054185205.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    3. XM_054329229.1XP_054185204.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      38472550..38500180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314854.1XP_054170829.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    2. XM_054314853.1XP_054170828.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    3. XM_054314851.1XP_054170826.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    4. XM_054314852.1XP_054170827.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36