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    IL11 interleukin 11 [ Homo sapiens (human) ]

    Gene ID: 3589, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL11provided by HGNC
    Official Full Name
    interleukin 11provided by HGNC
    Primary source
    HGNC:HGNC:5966
    See related
    Ensembl:ENSG00000095752 MIM:147681; AllianceGenome:HGNC:5966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGIF; IL-11
    Summary
    The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
    Expression
    Biased expression in endometrium (RPKM 2.0), appendix (RPKM 1.5) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL11 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55364382..55370463, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58459867..58465950, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55875750..55881831, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11025 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55871113-55871613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55874435-55875039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55880086-55880927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55881771-55882611 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6204 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55885919-55886140 Neighboring gene transmembrane protein 190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55890663-55891163 Neighboring gene transmembrane protein 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55895260-55896222

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. Zhang X, et al. J Immunol, 2015 Jun 1. PMID 25895532
    2. [Interleukin-11, an IL-6 like cytokine]. Guk KD, et al. Mol Biol (Mosk), 2011 Jan-Feb. PMID 21485496
    3. Association of interleukin-11 with mortality in patients with spontaneous basal ganglia haemorrhage. Tu CJ, et al. J Int Med Res, 2011. PMID 21986128
    4. Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation. Giuliani N, et al. Leukemia, 2012 Jun. PMID 22289923
    5. IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. Balakrishnan L, et al. Cell Commun Adhes, 2013 Aug. PMID 23631681

    See all (215) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
      Title: Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
    2. Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.
      Title: Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.
    3. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
      Title: Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
    4. Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
      Title: Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
    5. Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction.
      Title: Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction.
    6. Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
      Title: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
    7. IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFbeta.
      Title: IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
    8. Understanding interleukin 11 as a disease gene and therapeutic target.
      Title: Understanding interleukin 11 as a disease gene and therapeutic target.
    9. m[6]A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.
      Title: m(6)A modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.
    10. Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Ralpha/glycoprotein 130 signaling complex.
      Title: Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex.
    Submit: New GeneRIF Correction See all GeneRIFs (184)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells PubMed
    Tat tat HIV-1 Tat upregulates the expression of interleukin 11 gene (IL11) in mammary epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables interleukin-11 receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fat cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in interleukin-11-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in megakaryocyte differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in regulation of complement-dependent cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-11
    Names
    adipogenesis inhibitory factor
    oprelvekin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000641.4 → NP_000632.1  interleukin-11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000632.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC020922, AK315294, BF055151
      Consensus CDS
      CCDS12923.1
      UniProtKB/Swiss-Prot
      B4DQV5, P20809, Q96EB4
      UniProtKB/TrEMBL
      A8K3F7
      Related
      ENSP00000264563.1, ENST00000264563.7
      Conserved Domains (1) summary
      pfam07400
      Location:23 → 199
      IL11; Interleukin 11

    2. NM_001267718.2 → NP_001254647.1  interleukin-11 isoform 2

      See identical proteins and their annotated locations for NP_001254647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC020922, AK298973, BF055151
      Consensus CDS
      CCDS59423.1
      UniProtKB/Swiss-Prot
      P20809
      Related
      ENSP00000465705.1, ENST00000590625.5
      Conserved Domains (1) summary
      pfam07400
      Location:1 → 120
      IL11; Interleukin 11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55364382..55370463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58459867..58465950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20809.1 GenPept UniProtKB/Swiss-Prot:P20809

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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