PLXNB2 plexin B2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLXNB2provided by HGNC
Official Full Name: plexin B2provided by HGNC
Primary source: HGNC:HGNC:9104
See related: Ensembl:ENSG00000196576 MIM:604293; AllianceGenome:HGNC:9104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MM1; PLEXB2; lncFAL; Nbla00445; dJ402G11.3
Summary: Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.33

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (50274979..50307646, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (50781981..50815405, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (50713408..50746075, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo interaction screening reveals liver-derived constraints to metastasis.
Title: In vivo interaction screening reveals liver-derived constraints to metastasis.
Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.
Title: Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.
Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
Title: Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
Title: Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
Title: CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
Title: Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
Title: Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Title: Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Title: Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
Title: Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W70072 (e-PCR)
- UniSTS:57388

D22S1091 (e-PCR)
- UniSTS:153668

RH11264 (e-PCR)
- UniSTS:85620

NoName (e-PCR)
- UniSTS:486558

Plxnb2 (e-PCR), detects polymorphism
- UniSTS:525265

stdJ402G11A (e-PCR)
- UniSTS:181736

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	HDA more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-B2

Names: ferroptosis-associated lncRNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376864.1 → NP_001363793.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Conserved Domains (7) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1350 → 1883

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain
NM_001376865.1 → NP_001363794.1 plexin-B2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:918 → 1004

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:826 → 917

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:782 → 822

PSI; Plexin repeat

pfam08337
Location:1294 → 1827

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:1006 → 1116

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376866.1 → NP_001363795.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Related

ENSP00000409171.1, ENST00000449103.5

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376867.1 → NP_001363796.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376868.1 → NP_001363797.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376869.1 → NP_001363798.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376870.1 → NP_001363799.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376871.1 → NP_001363800.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376872.1 → NP_001363801.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376873.1 → NP_001363802.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376874.1 → NP_001363803.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376875.1 → NP_001363804.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376876.1 → NP_001363805.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376877.1 → NP_001363806.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376878.1 → NP_001363807.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376879.1 → NP_001363808.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376880.1 → NP_001363809.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376881.1 → NP_001363810.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376882.1 → NP_001363811.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376883.1 → NP_001363812.1 plexin-B2 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1263 → 1796

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376884.1 → NP_001363813.1 plexin-B2 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

cd12792
Location:1271 → 1811

RasGAP_plexin_B2; Ras-GTPase Activating Domain of plexin-B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376885.1 → NP_001363814.1 plexin-B2 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

cd12792
Location:1271 → 1811

RasGAP_plexin_B2; Ras-GTPase Activating Domain of plexin-B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001376886.1 → NP_001363815.1 plexin-B2 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AL022328, BX649592, CT010163

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:864 → 950

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:772 → 863

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:728 → 768

PSI; Plexin repeat

pfam08337
Location:1240 → 1773

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:952 → 1062

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_012401.4 → NP_036533.2 plexin-B2 isoform 3 precursor

See identical proteins and their annotated locations for NP_036533.2

Status: VALIDATED

Source sequence(s)

AB002313, AL022328, BC000221, BX649592, CT010163

Consensus CDS

CCDS43035.1

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7

Related

ENSP00000352288.4, ENST00000359337.9

Conserved Domains (8) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

smart00423
Location:468 → 518

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:759 → 799

PSI; Plexin repeat

pfam08337
Location:1271 → 1804

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:526 → 613

TIG_plexin; TIG domain

cl15674
Location:983 → 1093

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

50274979..50307646 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441264.1 → XP_047297220.1 plexin-B2 isoform X2

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7
XM_011530682.3 → XP_011528984.1 plexin-B2 isoform X1

Conserved Domains (6) summary

cd11276
Location:90 → 530

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

cd01179
Location:958 → 1044

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:866 → 957

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:532 → 580

PSI; Plexin repeat

pfam01833
Location:1046 → 1154

TIG; IPT/TIG domain

pfam08337
Location:1334 → 1868

Plexin_cytopl; Plexin cytoplasmic RasGAP domain
XM_047441263.1 → XP_047297219.1 plexin-B2 isoform X2

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7
XM_047441262.1 → XP_047297218.1 plexin-B2 isoform X2

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7
XM_047441261.1 → XP_047297217.1 plexin-B2 isoform X2

UniProtKB/Swiss-Prot

A6QRH0, O15031, Q7KZU3, Q9BSU7
XM_047441266.1 → XP_047297222.1 plexin-B2 isoform X4

Related

ENST00000479701.5
XM_047441265.1 → XP_047297221.1 plexin-B2 isoform X3