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    SULT1A4 sulfotransferase family 1A member 4 [ Homo sapiens (human) ]

    Gene ID: 445329, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SULT1A4provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 4provided by HGNC
    Primary source
    HGNC:HGNC:30004
    See related
    Ensembl:ENSG00000213648 MIM:615819; AllianceGenome:HGNC:30004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STM; HAST3; M-PST; ST1A3; ST1A4; TL-PST; ST1A3/ST1A4
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
    Expression
    Broad expression in duodenum (RPKM 135.4), small intestine (RPKM 94.3) and 23 other tissues See more
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    Genomic context

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    See SULT1A4 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29459913..29464966)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (29741703..29746756)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29471234..29476287)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene BOLA2-SMG1P6 readthrough Neighboring gene coronin 1A pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:29465349-29466088 Neighboring gene SLX1B-SULT1A4 readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29466829-29467566 Neighboring gene bolA family member 2 Neighboring gene SLX1 homolog B, structure-specific endonuclease subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29470053-29470888 Neighboring gene SAGA complex associated factor 29 pseudogene Neighboring gene phospholipase A2 group XH, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. Wood TC, et al. Biochem Biophys Res Commun, 1994 Feb 15. PMID 8117269
    2. Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes. Bairam AF, et al. Pharmacogenet Genomics, 2019 Jul. PMID 31145702, Free PMC Article
    3. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3. Bairam AF, et al. Arch Biochem Biophys, 2018 Jun 15. PMID 29705271, Free PMC Article
    4. Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example. Bradley ME, et al. BMC Evol Biol, 2005 Mar 7. PMID 15752422, Free PMC Article
    5. Crystal structure of human catecholamine sulfotransferase. Bidwell LM, et al. J Mol Biol, 1999 Oct 29. PMID 10543947

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
      Title: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.
    2. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
      Title: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough SLX1B-SULT1A4

    Readthrough gene: SLX1B-SULT1A4, Included gene: SLX1B

    Homology

    Clone Names

    • FLJ54864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to dopamine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in flavonoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1A4
    Names
    SLX1B-SULT1A4
    Sulfotransferase 1A3
    aryl sulfotransferase 1A3/1A4
    catecholamine-sulfating phenol sulfotransferase
    monoamine-sulfating phenol sulfotransferase
    placental estrogen sulfotransferase
    sulfokinase
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
    sulfotransferase, monoamine-preferring
    thermolabile phenol sulfotransferase
    NP_001017390.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017390.3 → NP_001017390.1  sulfotransferase 1A4

      See identical proteins and their annotated locations for NP_001017390.1

      Status: REVIEWED

      Source sequence(s)
      AC133555
      Consensus CDS
      CCDS32427.1
      UniProtKB/Swiss-Prot
      B4DNV0, O95603, P0DMM9, P0DMN0, P50224, Q1ET66, Q6ZWJ5
      UniProtKB/TrEMBL
      B3KT14, Q1ET61, Q1ET62, Q1ET63, Q2TAB3
      Related
      ENSP00000353600.8, ENST00000360423.12
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      29459913..29464966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      29741703..29746756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017389.1: Suppressed sequence

      Description
      NM_001017389.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_001017391.1: Suppressed sequence

      Description
      NM_001017391.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DMM9.1 GenPept UniProtKB/Swiss-Prot:P0DMM9
    P0DMN0.1 GenPept UniProtKB/Swiss-Prot:P0DMN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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