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    ZNF221 zinc finger protein 221 [ Homo sapiens (human) ]

    Gene ID: 7638, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF221provided by HGNC
    Official Full Name
    zinc finger protein 221provided by HGNC
    Primary source
    HGNC:HGNC:13014
    See related
    Ensembl:ENSG00000159905 AllianceGenome:HGNC:13014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.3), brain (RPKM 1.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF221 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43951228..43981613)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46774167..46793142)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44455380..44471861)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14745 Neighboring gene ZNF45 antisense RNA 1 Neighboring gene zinc finger protein 45 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10732 Neighboring gene zinc finger protein 155 Neighboring gene ZNF230 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14748 Neighboring gene zinc finger protein 230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41. Rosati M, et al. Cytogenet Cell Genet, 1999. PMID 10449920
    2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC138186, MGC141986

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 221

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297588.2 → NP_001284517.1  zinc finger protein 221

      See identical proteins and their annotated locations for NP_001284517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC006213, AF187987, AK314207, DA493401, KF459580
      Consensus CDS
      CCDS12633.1
      UniProtKB/Swiss-Prot
      A0A087WT08, B2RAI6, K7EIT6, Q2M2H2, Q9P1U8, Q9UK13
      Related
      ENSP00000467367.1, ENST00000587682.6
      Conserved Domains (3) summary
      COG5048
      Location:166 → 576
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:30 → 70
      KRAB; KRAB box

    2. NM_001297589.2 → NP_001284518.1  zinc finger protein 221

      See identical proteins and their annotated locations for NP_001284518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC006213, BP337374, KF459580
      Consensus CDS
      CCDS12633.1
      UniProtKB/Swiss-Prot
      A0A087WT08, B2RAI6, K7EIT6, Q2M2H2, Q9P1U8, Q9UK13
      Conserved Domains (3) summary
      COG5048
      Location:166 → 576
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:30 → 70
      KRAB; KRAB box

    3. NM_013359.3 → NP_037491.2  zinc finger protein 221

      See identical proteins and their annotated locations for NP_037491.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC006213, AF187987, BC111981
      Consensus CDS
      CCDS12633.1
      UniProtKB/Swiss-Prot
      A0A087WT08, B2RAI6, K7EIT6, Q2M2H2, Q9P1U8, Q9UK13
      Related
      ENSP00000251269.4, ENST00000251269.9
      Conserved Domains (3) summary
      COG5048
      Location:166 → 576
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:30 → 70
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43951228..43981613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439352.1 → XP_047295308.1  zinc finger protein 221 isoform X1

      UniProtKB/Swiss-Prot
      A0A087WT08, B2RAI6, K7EIT6, Q2M2H2, Q9P1U8, Q9UK13

    RNA

    1. XR_007066976.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46774167..46793142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321986.1 → XP_054177961.1  zinc finger protein 221 isoform X1

    RNA

    1. XR_008485179.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK13.4 GenPept UniProtKB/Swiss-Prot:Q9UK13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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