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    ZNF623 zinc finger protein 623 [ Homo sapiens (human) ]

    Gene ID: 9831, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF623provided by HGNC
    Official Full Name
    zinc finger protein 623provided by HGNC
    Primary source
    HGNC:HGNC:29084
    See related
    Ensembl:ENSG00000183309 AllianceGenome:HGNC:29084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 5.7), thyroid (RPKM 4.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF623 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143636019..143653730)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144785446..144802812)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144718189..144735900)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144699896-144700500 Neighboring gene uncharacterized LOC105375798 Neighboring gene GDP-L-fucose synthase Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105375799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751216-144751716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751717-144752217 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144764224-144764449 Neighboring gene zinc finger protein 707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MxA interacts with and is modified by the SUMOylation machinery. Brantis-de-Carvalho CE, et al. Exp Cell Res, 2015 Jan 1. PMID 25447205
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1998 Jun 30. PMID 9734811
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103965, MGC104128

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 623

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082480.2 → NP_001075949.1  zinc finger protein 623 isoform 2

      See identical proteins and their annotated locations for NP_001075949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB014528, BC112898
      Consensus CDS
      CCDS47931.1
      UniProtKB/Swiss-Prot
      O75123
      UniProtKB/TrEMBL
      A0A0A0MT18
      Related
      ENSP00000411139.2, ENST00000458270.2
      Conserved Domains (4) summary
      COG5048
      Location:83 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210 → 234
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001261843.2 → NP_001248772.1  zinc finger protein 623 isoform 2

      See identical proteins and their annotated locations for NP_001248772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB014528, AK294695, DC355766, DC380463
      Consensus CDS
      CCDS47931.1
      UniProtKB/Swiss-Prot
      O75123
      UniProtKB/TrEMBL
      A0A0A0MT18
      Related
      ENSP00000435232.1, ENST00000526926.6
      Conserved Domains (4) summary
      COG5048
      Location:83 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210 → 234
      zf-H2C2_2; Zinc-finger double domain

    3. NM_014789.3 → NP_055604.3  zinc finger protein 623 isoform 1

      See identical proteins and their annotated locations for NP_055604.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC067516, BC067517, BX477157, DA100931, DA211779, DB161675, DB227885
      Consensus CDS
      CCDS34957.1
      UniProtKB/Swiss-Prot
      A4FU80, B4DGP3, E7ENV5, O75123
      Related
      ENSP00000445979.1, ENST00000501748.3
      Conserved Domains (2) summary
      COG5048
      Location:123 → 494
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143636019..143653730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422501.1 → XP_047278457.1  zinc finger protein 623 isoform X1

    2. XM_006716708.4 → XP_006716771.1  zinc finger protein 623 isoform X1

      See identical proteins and their annotated locations for XP_006716771.1

      UniProtKB/TrEMBL
      A0A0A0MT18
      Conserved Domains (4) summary
      COG5048
      Location:83 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210 → 234
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047422498.1 → XP_047278454.1  zinc finger protein 623 isoform X1

    4. XM_047422499.1 → XP_047278455.1  zinc finger protein 623 isoform X1

    5. XM_047422500.1 → XP_047278456.1  zinc finger protein 623 isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      111849..129199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328782.1 → XP_054184757.1  zinc finger protein 623 isoform X1

    2. XM_054328781.1 → XP_054184756.1  zinc finger protein 623 isoform X1

    3. XM_054328778.1 → XP_054184753.1  zinc finger protein 623 isoform X1

    4. XM_054328779.1 → XP_054184754.1  zinc finger protein 623 isoform X1

    5. XM_054328783.1 → XP_054184758.1  zinc finger protein 623 isoform X1

    6. XM_054328780.1 → XP_054184755.1  zinc finger protein 623 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144785446..144802812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361635.1 → XP_054217610.1  zinc finger protein 623 isoform X1

    2. XM_054361634.1 → XP_054217609.1  zinc finger protein 623 isoform X1

    3. XM_054361633.1 → XP_054217608.1  zinc finger protein 623 isoform X1

    4. XM_054361636.1 → XP_054217611.1  zinc finger protein 623 isoform X1

    5. XM_054361632.1 → XP_054217607.1  zinc finger protein 623 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75123.3 GenPept UniProtKB/Swiss-Prot:O75123

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