MGRN1 mahogunin ring finger 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MGRN1provided by HGNC
Official Full Name: mahogunin ring finger 1provided by HGNC
Primary source: HGNC:HGNC:20254
See related: Ensembl:ENSG00000102858 MIM:607559; AllianceGenome:HGNC:20254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNF156
Summary: Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (4624826..4690972)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (4654281..4720424)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (4674827..4740973)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.
Title: MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.
Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.
Title: Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.
epletion of MGRN1 activity may hamper physiologically important processes like mitochondrial movement in neuronal processes and intracellular transport of ligands through the endosomal pathway thereby contributing to the pathogenesis of neurodegeneration in certain types of prion diseases
Title: MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.
In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase.
Title: Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.
Hypomethylation of CpG sites in RPTOR, MGRN1 and RAPSN in blood is associated with breast cancer.
Title: DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.
Regulation of Mfn1 by MGRN1 and the proteasome modulates mitochondrial fusion.
Title: Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion.
With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1.
Title: Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.
Catalytic inactivation of MGRN1 results in elevated levels of GP78 and a consequential increase in the initiation of mitophagy.
Title: Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.
Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
Title: Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration
Title: Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78602 (e-PCR)
- UniSTS:24280

RH66031 (e-PCR)
- UniSTS:12270

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MGRN1

Names: RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1; mahogunin RING finger protein 1; mahogunin ring finger 1, E3 ubiquitin protein ligase; probable E3 ubiquitin-protein ligase MGRN1

NP_001135761.2

EC 2.3.2.27

NP_001135762.1

EC 2.3.2.27

NP_001135763.2

EC 2.3.2.27

NP_056061.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142289.3 → NP_001135761.2 E3 ubiquitin-protein ligase MGRN1 isoform 2

See identical proteins and their annotated locations for NP_001135761.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC023830, DA590130, EF471397

Consensus CDS

CCDS59256.1

UniProtKB/TrEMBL

K7EPJ5

Related

ENSP00000468819.1, ENST00000588994.5

Conserved Domains (3) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:273 → 449

rad18; DNA repair protein rad18

pfam13920
Location:274 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_001142290.3 → NP_001135762.1 E3 ubiquitin-protein ligase MGRN1 isoform 3

See identical proteins and their annotated locations for NP_001135762.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AB011116, AC023830, DA590130

Consensus CDS

CCDS45402.1

UniProtKB/Swiss-Prot

A4URL3, A4URL4, O60291, Q86W76

UniProtKB/TrEMBL

K7EPJ5

Related

ENSP00000382487.4, ENST00000399577.9

Conserved Domains (2) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

pfam13920
Location:274 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_001142291.3 → NP_001135763.2 E3 ubiquitin-protein ligase MGRN1 isoform 4

See identical proteins and their annotated locations for NP_001135763.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC023830, DA590130, EF471398

Consensus CDS

CCDS45401.2

UniProtKB/TrEMBL

K7EPJ5

Related

ENSP00000393311.2, ENST00000415496.5

Conserved Domains (3) summary

PHA02929
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

TIGR00599
Location:273 → 449

rad18; DNA repair protein rad18

pfam13920
Location:274 → 319

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_015246.4 → NP_056061.1 E3 ubiquitin-protein ligase MGRN1 isoform 1

See identical proteins and their annotated locations for NP_056061.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC023830, BC050389, DA590130

Consensus CDS

CCDS42115.1

UniProtKB/TrEMBL

K7EPJ5

Related

ENSP00000262370.6, ENST00000262370.12

Conserved Domains (2) summary

cd16789
Location:277 → 317

mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins

cl27165
Location:232 → 331

PHA02929; N1R/p28-like protein; Provisional

RNA

NR_102267.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC023830, AK299052