SPDYE8 speedy/RINGO cell cycle regulator family member E8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPDYE8provided by HGNC
Official Full Name: speedy/RINGO cell cycle regulator family member E8provided by HGNC
Primary source: HGNC:HGNC:33771
See related: Ensembl:ENSG00000273520 AllianceGenome:HGNC:33771
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPDYE9; SPDYE8P
Summary: Enables acetylcholine receptor regulator activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 7.7), skin (RPKM 2.0) and 23 other tissues See more
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Genomic context

Location:: 7q11.23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (73019719..73029766, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (74247948..74258006, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (72490248..72500313, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative speedy protein E8

Names: Williams Beuren syndrome chromosome region 19 pseudogene; speedy homolog E pseudogene; speedy homolog E8, pseudogene; speedy/RINGO cell cycle regulator family member E1 pseudogene; speedy/RINGO cell cycle regulator family member E8, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382525.2 → NP_001369454.1 putative speedy protein E8

Status: VALIDATED

Source sequence(s)

AC211476

Consensus CDS

CCDS94114.1

UniProtKB/Swiss-Prot

A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0

Related

ENSP00000498819.1, ENST00000333385.11

Conserved Domains (1) summary

pfam11357
Location:107 → 261

Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

73019719..73029766 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

74247948..74258006 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_006254.1: Suppressed sequence

Description

NG_006254.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
NM_001023562.1: Suppressed sequence

Description

NM_001023562.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
NM_001032389.2: Suppressed sequence

Description

NM_001032389.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
NR_003664.2: Suppressed sequence

Description

NR_003664.2: This RefSeq was removed because it is now thought that this gene does encode a protein.