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    POTEG POTE ankyrin domain family member G [ Homo sapiens (human) ]

    Gene ID: 404785, updated on 17-Sep-2024

    Summary

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    Official Symbol
    POTEGprovided by HGNC
    Official Full Name
    POTE ankyrin domain family member Gprovided by HGNC
    Primary source
    HGNC:HGNC:33896
    See related
    Ensembl:ENSG00000187537 MIM:608916; AllianceGenome:HGNC:33896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A26C2; ACTBL1; POTE14; POTE22; CT104.4; POTE-14; POTE14alpha
    Expression
    Restricted expression toward prostate (RPKM 10.5) See more
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    Genomic context

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    See POTEG in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19402486..19434341, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (13713835..13745718, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (19553365..19585220)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene LINC01297-DUXAP10-NBEAP6 readthrough Neighboring gene double homeobox A pseudogene 10 Neighboring gene BMS1 pseudogene 17 Neighboring gene MPRA-validated peak2108 silencer Neighboring gene long intergenic non-protein coding RNA 1297 Neighboring gene GRAM domain containing 4 pseudogene 3 Neighboring gene uncharacterized LOC101929572 Neighboring gene RNA, U6 small nuclear 1268, pseudogene Neighboring gene uncharacterized LOC124903277 Neighboring gene mediator complex subunit 15 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Bera TK, et al. Gene, 2004 Aug 4. PMID 15276201
    2. Identification of a novel actin isoform in hepatocellular carcinoma. Chang KW, et al. Hepatol Res, 2006 Sep. PMID 16824795
    3. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
    4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    POTE ankyrin domain family member G
    Names
    ANKRD26-like family C member 2
    cancer/testis antigen family 104, member 4
    prostate, ovary, testis-expressed protein on chromosome 14
    protein expressed in prostate, ovary, testis, and placenta 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005356.3 → NP_001005356.1  POTE ankyrin domain family member G

      See identical proteins and their annotated locations for NP_001005356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AL512624, AY462874, AY465171, BC127623, CV341500
      Consensus CDS
      CCDS73610.1
      UniProtKB/Swiss-Prot
      A1L153, A6NMI9, Q6S5H5, Q6S5H6, Q6S8J2
      UniProtKB/TrEMBL
      A0A087X187
      Related
      ENSP00000450853.2, ENST00000547848.5
      Conserved Domains (4) summary
      cd00204
      Location:167 → 292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:177 → 269
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:143 → 193
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:238 → 269
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_027480.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL512624, AY462874, AY465172, BC127623, CV341500
      Related
      ENST00000622767.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      19402486..19434341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      13713835..13745718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005357.1: Suppressed sequence

      Description
      NM_001005357.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_207513.2: Suppressed sequence

      Description
      NM_207513.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6S5H5.5 GenPept UniProtKB/Swiss-Prot:Q6S5H5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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