H3C15 H3 clustered histone 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: H3C15provided by HGNC
Official Full Name: H3 clustered histone 15provided by HGNC
Primary source: HGNC:HGNC:20505
See related: Ensembl:ENSG00000203852 AllianceGenome:HGNC:20505
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H3/n; H3/o; H3C13; H3C14; HIST2H3A
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]
Orthologs: all
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Genomic context

Location:: 1q21.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (149852608..149853125)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (148976743..148977260)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (149824170..149824687)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulated by zinc and upregulated by docosahexaenoate in a neuroblastoma cell line.
Title: Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells.
histone H3 Lys(23) propionylation may provide a novel epigenetic regulatory mark for cell metabolism
Title: Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells.
the evolving role of histone H3 phosphorylation and demonstrate a direct, functional, and histone-modification-regulated association of SRp20 and ASF/SF2 with chromatin.
Title: Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation.
These results suggest that Lysine 56 acetylation of Histone H3 is involved in the human core transcriptional network of pluripotency.
Title: Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.
analysis of interactions between WDR5, the catalytic subunit, MLL, and the substrate, histone H3, of the MLL complex
Title: WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.
expression of histone 3 is highly related to modulation of cytokeratin 18 and might play an important role in tumorigenesis of hepatocellular carcinoma
Title: Possible relation between histone 3 and cytokeratin 18 in human hepatocellular carcinoma.
In syngeneic human breast-derived cell lines, one diploid and non-transformed, the other derived from a ductal carcinoma, the loss of H3 phosphorylation is significantly more sensitive to cAMP concentration in the transformed cell line.
Title: cAMP signaling induces rapid loss of histone H3 phosphorylation in mammary adenocarcinoma-derived cell lines.
the crystal structure of WDR5 bound to a histone H3
Title: Molecular recognition of histone H3 by the WD40 protein WDR5.
the high-resolution X-ray structures of WDR5 in the unliganded form and complexed with histone H3 peptides having unmodified and mono-, di- and trimethylated K4
Title: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482157

HIST2H2AA__3118 (e-PCR)
- UniSTS:471461

RH69022 (e-PCR)
- UniSTS:53173

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H3.2

Names: H3-clustered histone 13; H3-clustered histone 14; histone 2, H3a; histone H3/o; histone cluster 2 H3 family member a; histone cluster 2, H3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.