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    SLC26A11 solute carrier family 26 member 11 [ Homo sapiens (human) ]

    Gene ID: 284129, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SLC26A11provided by HGNC
    Official Full Name
    solute carrier family 26 member 11provided by HGNC
    Primary source
    HGNC:HGNC:14471
    See related
    Ensembl:ENSG00000181045 MIM:610117; AllianceGenome:HGNC:14471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in adrenal (RPKM 8.3), spleen (RPKM 6.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q25.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80220427..80253500)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81120848..81153937)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78194226..78227299)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78120154-78120868 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78120869-78121581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78121582-78122295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78122296-78123008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78126203-78126704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78126705-78127204 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:78129355-78129892 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene Sharpr-MPRA regulatory region 5287 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78151904-78153103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78163065-78163581 Neighboring gene caspase recruitment domain family member 14 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:78178385-78179584 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:78183891-78184046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78195951-78196788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78196789-78197626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78200105-78200606 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78209849-78210638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78210639-78211426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78227308-78228024 Neighboring gene SLC26A11-RNF213 intergenic CAGE-defined mid-level expression enhancer Neighboring gene CRISPRi-validated cis-regulatory element chr17.5742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78237270-78237826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78247837-78248435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78251821-78252439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78258533-78259093 Neighboring gene ring finger protein 213 Neighboring gene RNF213 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78345568-78346767 Neighboring gene MPRA-validated peak3024 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78354122-78354622 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:78359110-78360309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78369069-78369570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371216-78371723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371724-78372230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12935 Neighboring gene microRNA 4730 Neighboring gene endonuclease V

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Renal physiology of SLC26 anion exchangers. Sindić A, et al. Curr Opin Nephrol Hypertens, 2007 Sep. PMID 17693766
    2. SLC26 chloride/base exchangers in the kidney in health and disease. Soleimani M, et al. Semin Nephrol, 2006 Sep. PMID 17071331
    3. Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. Vincourt JB, et al. FASEB J, 2003 May. PMID 12626430
    4. The proteome of lysosomes. Schröder BA, et al. Proteomics, 2010 Nov. PMID 20957757
    5. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Palmieri M, et al. Hum Mol Genet, 2011 Oct 1. PMID 21752829

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC26A11 protein localizes in lysosomes in HeLa cells
      Title: Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chloride:bicarbonate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoatomic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in oxalate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sodium-independent sulfate anion transporter
    Names
    solute carrier family 26 (anion exchanger), member 11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166347.2 → NP_001159819.1  sodium-independent sulfate anion transporter

      See identical proteins and their annotated locations for NP_001159819.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI963799, AK075248, AK315132, BC035900, DA290933
      Consensus CDS
      CCDS11771.2
      UniProtKB/Swiss-Prot
      B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
      Related
      ENSP00000355384.3, ENST00000361193.8
      Conserved Domains (3) summary
      cd07042
      Location:470 → 564
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:35 → 559
      sulP; high affinity sulphate transporter 1
      cl06211
      Location:221 → 334
      DUF1341; Protein of unknown function (DUF1341)

    2. NM_001166348.2 → NP_001159820.1  sodium-independent sulfate anion transporter

      See identical proteins and their annotated locations for NP_001159820.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI963799, AK075248, AL833468, DA290933
      Consensus CDS
      CCDS11771.2
      UniProtKB/Swiss-Prot
      B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
      Related
      ENSP00000440724.2, ENST00000546047.6
      Conserved Domains (3) summary
      cd07042
      Location:470 → 564
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:35 → 559
      sulP; high affinity sulphate transporter 1
      cl06211
      Location:221 → 334
      DUF1341; Protein of unknown function (DUF1341)

    3. NM_001166349.2 → NP_001159821.1  sodium-independent sulfate anion transporter

      See identical proteins and their annotated locations for NP_001159821.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AF331524, AF345195, AI963799, AK075248, DA290933
      Consensus CDS
      CCDS11771.2
      UniProtKB/Swiss-Prot
      B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
      Related
      ENSP00000459470.1, ENST00000572725.5
      Conserved Domains (3) summary
      cd07042
      Location:470 → 564
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:35 → 559
      sulP; high affinity sulphate transporter 1
      cl06211
      Location:221 → 334
      DUF1341; Protein of unknown function (DUF1341)

    4. NM_173626.4 → NP_775897.3  sodium-independent sulfate anion transporter

      See identical proteins and their annotated locations for NP_775897.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC123764, AI963799, AK075248, DA290933
      Consensus CDS
      CCDS11771.2
      UniProtKB/Swiss-Prot
      B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03
      Related
      ENSP00000403998.3, ENST00000411502.7
      Conserved Domains (3) summary
      cd07042
      Location:470 → 564
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:35 → 559
      sulP; high affinity sulphate transporter 1
      cl06211
      Location:221 → 334
      DUF1341; Protein of unknown function (DUF1341)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      80220427..80253500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435806.1 → XP_047291762.1  sodium-independent sulfate anion transporter isoform X2

      UniProtKB/Swiss-Prot
      B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03

    2. XM_006721833.3 → XP_006721896.1  sodium-independent sulfate anion transporter isoform X1

      Conserved Domains (3) summary
      cd07042
      Location:494 → 588
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:35 → 583
      sulP; high affinity sulphate transporter 1
      cl06211
      Location:245 → 358
      DUF1341; Protein of unknown function (DUF1341)

    3. XM_017024507.2 → XP_016879996.1  sodium-independent sulfate anion transporter isoform X1

      Conserved Domains (3) summary
      cd07042
      Location:494 → 588
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:35 → 583
      sulP; high affinity sulphate transporter 1
      cl06211
      Location:245 → 358
      DUF1341; Protein of unknown function (DUF1341)

    4. XM_017024505.2 → XP_016879994.2  sodium-independent sulfate anion transporter isoform X1

    5. XM_047435808.1 → XP_047291764.1  sodium-independent sulfate anion transporter isoform X4

    6. XM_047435807.1 → XP_047291763.1  sodium-independent sulfate anion transporter isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      81120848..81153937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315800.1 → XP_054171775.1  sodium-independent sulfate anion transporter isoform X2

      UniProtKB/Swiss-Prot
      B2RCI7, Q86VX1, Q86WA9, Q86YX7, Q8IV11, Q8N2I1, Q8NG03

    2. XM_054315798.1 → XP_054171773.1  sodium-independent sulfate anion transporter isoform X1

    3. XM_054315799.1 → XP_054171774.1  sodium-independent sulfate anion transporter isoform X1

    4. XM_054315797.1 → XP_054171772.1  sodium-independent sulfate anion transporter isoform X1

    5. XM_054315802.1 → XP_054171777.1  sodium-independent sulfate anion transporter isoform X4

    6. XM_054315801.1 → XP_054171776.1  sodium-independent sulfate anion transporter isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WA9.2 GenPept UniProtKB/Swiss-Prot:Q86WA9

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