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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_014203.3 → NP_055018.2 AP-2 complex subunit alpha-1 isoform 1
See identical proteins and their annotated locations for NP_055018.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform of this protein.
- Source sequence(s)
-
AC006942, AC011495
- Consensus CDS
-
CCDS46148.1
- UniProtKB/Swiss-Prot
- O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070
- Related
- ENSP00000351926.4, ENST00000359032.10
- Conserved Domains (4) summary
-
- sd00044
Location:332 → 355
- HEAT; HEAT repeat [structural motif]
- pfam01602
Location:29 → 591
- Adaptin_N; Adaptin N terminal region
- pfam02296
Location:864 → 972
- Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
- pfam02883
Location:751 → 858
- Alpha_adaptinC2; Adaptin C-terminal domain
-
NM_130787.3 → NP_570603.2 AP-2 complex subunit alpha-1 isoform 2
See identical proteins and their annotated locations for NP_570603.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks a 66 nt internal exon but maintains the reading frame, as compared to variant 1. Isoform 2 lacks 22 internal aa as compared to isoform 1.
- Source sequence(s)
-
AC006942, AC011495
- Consensus CDS
-
CCDS46149.1
- UniProtKB/Swiss-Prot
-
O95782
- Related
- ENSP00000346246.4, ENST00000354293.10
- Conserved Domains (4) summary
-
- sd00044
Location:332 → 355
- HEAT; HEAT repeat [structural motif]
- pfam01602
Location:29 → 591
- Adaptin_N; Adaptin N terminal region
- pfam02296
Location:842 → 950
- Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
- pfam02883
Location:729 → 836
- Alpha_adaptinC2; Adaptin C-terminal domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000019.10 Reference GRCh38.p14 Primary Assembly
- Range
-
49767001..49807114
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011526556.3 → XP_011524858.1 AP-2 complex subunit alpha-1 isoform X1
- Conserved Domains (4) summary
-
- smart00809
Location:772 → 875
- Alpha_adaptinC2; Adaptin C-terminal domain
- pfam01602
Location:46 → 608
- Adaptin_N; Adaptin N terminal region
- pfam02296
Location:881 → 989
- Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
- sd00044
Location:349 → 372
- HEAT; HEAT repeat [structural motif]
-
XM_011526557.4 → XP_011524859.1 AP-2 complex subunit alpha-1 isoform X2
- Conserved Domains (4) summary
-
- smart00809
Location:750 → 853
- Alpha_adaptinC2; Adaptin C-terminal domain
- pfam01602
Location:46 → 608
- Adaptin_N; Adaptin N terminal region
- pfam02296
Location:859 → 967
- Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
- sd00044
Location:349 → 372
- HEAT; HEAT repeat [structural motif]
Alternate T2T-CHM13v2.0
Genomic
-
NC_060943.1 Alternate T2T-CHM13v2.0
- Range
-
52767146..52807252
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054320019.1 → XP_054175994.1 AP-2 complex subunit alpha-1 isoform X1
-
XM_054320020.1 → XP_054175995.1 AP-2 complex subunit alpha-1 isoform X2