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    LGALS8 galectin 8 [ Homo sapiens (human) ]

    Gene ID: 3964, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LGALS8provided by HGNC
    Official Full Name
    galectin 8provided by HGNC
    Primary source
    HGNC:HGNC:6569
    See related
    Ensembl:ENSG00000116977 MIM:606099; AllianceGenome:HGNC:6569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gal-8; PCTA1; PCTA-1; Po66-CBP
    Summary
    This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (236518214..236552981)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (235919116..235953936)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236681514..236716281)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2821 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:236528741-236529521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2822 Neighboring gene MPRA-validated peak784 silencer Neighboring gene EDAR associated via death domain Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236553124-236553300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236588023-236588524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2003 Neighboring gene NANOG hESC enhancer GRCh37_chr1:236634853-236635427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236636352-236636876 Neighboring gene Sharpr-MPRA regulatory region 2344 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236679601-236679779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2004 Neighboring gene enolase 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 1811 Neighboring gene LGALS8 antisense RNA 1 Neighboring gene MPRA-validated peak785 silencer Neighboring gene MPRA-validated peak786 silencer Neighboring gene HEAT repeat containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2825 Neighboring gene MPRA-validated peak787 silencer Neighboring gene control region 3 heart enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2005 Neighboring gene VISTA enhancer hs2135 Neighboring gene actinin alpha 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2827 Neighboring gene ribosomal protein SA pseudogene 21 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population. Pál Z, et al. Biochim Biophys Acta, 2012 Oct. PMID 22683700
    2. Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts. Smith PC, et al. J Periodontal Res, 2020 Oct. PMID 32449990
    3. Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Massardo L, et al. Lupus, 2009 May. PMID 19395456
    4. Crystallization and preliminary X-ray diffraction analysis of a protease-resistant mutant form of human galectin-8. Yoshida H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 May 1. PMID 19407390, Free PMC Article
    5. Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7. Cludts S, et al. Anticancer Res, 2009 Dec. PMID 20044599

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Galectin-8 Contributes to Human Trophoblast Cell Invasion.
      Title: Galectin-8 Contributes to Human Trophoblast Cell Invasion.
    2. Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer.
      Title: Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer.
    3. Hypoxia-induced galectin-8 maintains stemness in glioma stem cells via autophagy regulation.
      Title: Hypoxia-induced galectin-8 maintains stemness in glioma stem cells via autophagy regulation.
    4. Association of GAL-8 promoter methylation levels with coronary plaque inflammation.
      Title: Association of GAL-8 promoter methylation levels with coronary plaque inflammation.
    5. Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
      Title: Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
    6. Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
      Title: Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
    7. Galectin-8 and -9 as prognostic factors for cervical cancer.
      Title: Galectin-8 and -9 as prognostic factors for cervical cancer.
    8. Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.
      Title: Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.
    9. circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.
      Title: circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.
    10. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
      Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LGALS8 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymphatic endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    galectin-8
    Names
    Po66 carbohydrate binding protein
    galectin-8g
    lectin, galactoside-binding, soluble, 8
    po66 carbohydrate-binding protein
    prostate carcinoma tumor antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006499.5 → NP_006490.3  galectin-8 isoform a

      See identical proteins and their annotated locations for NP_006490.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 4 encode the longer isoform (a).
      Source sequence(s)
      AK098613, AL359921, BC016486, DB053616
      Consensus CDS
      CCDS1611.1
      UniProtKB/TrEMBL
      F6V2D4
      Related
      ENSP00000408657.2, ENST00000450372.6
      Conserved Domains (2) summary
      smart00908
      Location:236 → 356
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18 → 151
      Gal-bind_lectin; Galactoside-binding lectin

    2. NM_201543.4 → NP_963837.1  galectin-8 isoform b

      See identical proteins and their annotated locations for NP_963837.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AL359921, BC016486, DB053616
      Consensus CDS
      CCDS1612.1
      UniProtKB/Swiss-Prot
      O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
      UniProtKB/TrEMBL
      Q59E97
      Related
      ENSP00000342139.6, ENST00000341872.10
      Conserved Domains (2) summary
      smart00908
      Location:194 → 314
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18 → 151
      Gal-bind_lectin; Galactoside-binding lectin

    3. NM_201544.4 → NP_963838.1  galectin-8 isoform b

      See identical proteins and their annotated locations for NP_963838.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AL359921, BC016486
      Consensus CDS
      CCDS1612.1
      UniProtKB/Swiss-Prot
      O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
      UniProtKB/TrEMBL
      Q59E97
      Related
      ENSP00000355543.4, ENST00000366584.9
      Conserved Domains (2) summary
      smart00908
      Location:194 → 314
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18 → 151
      Gal-bind_lectin; Galactoside-binding lectin

    4. NM_201545.2 → NP_963839.1  galectin-8 isoform a

      See identical proteins and their annotated locations for NP_963839.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode a longer isoform (a).
      Source sequence(s)
      AK098613, AL359921, BC016486, BP371701
      Consensus CDS
      CCDS1611.1
      UniProtKB/TrEMBL
      F6V2D4
      Related
      ENSP00000309576.2, ENST00000352231.6
      Conserved Domains (2) summary
      smart00908
      Location:236 → 356
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18 → 151
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      236518214..236552981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420410.1 → XP_047276366.1  galectin-8 isoform X1

      Related
      ENSP00000435460.1, ENST00000526589.5

    2. XM_047420411.1 → XP_047276367.1  galectin-8 isoform X1

    3. XM_047420409.1 → XP_047276365.1  galectin-8 isoform X1

    4. XM_047420416.1 → XP_047276372.1  galectin-8 isoform X3

      UniProtKB/Swiss-Prot
      O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34

    5. XM_011544188.4 → XP_011542490.1  galectin-8 isoform X2

      Conserved Domains (2) summary
      smart00908
      Location:236 → 310
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:18 → 151
      Gal-bind_lectin; Galactoside-binding lectin

    6. XM_017001274.3 → XP_016856763.1  galectin-8 isoform X4

      UniProtKB/TrEMBL
      E9PN19

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      235919116..235953936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336565.1 → XP_054192540.1  galectin-8 isoform X1

    2. XM_054336566.1 → XP_054192541.1  galectin-8 isoform X1

    3. XM_054336564.1 → XP_054192539.1  galectin-8 isoform X1

    4. XM_054336567.1 → XP_054192542.1  galectin-8 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00214.4 GenPept UniProtKB/Swiss-Prot:O00214

    Gene LinkOut

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